经颅交流电刺激频率和强度对青年和老年人运动皮质兴奋性的影响。

IF 2.1 3区 医学 Q3 NEUROSCIENCES
Journal of neurophysiology Pub Date : 2025-08-01 Epub Date: 2025-07-21 DOI:10.1152/jn.00147.2025
John Cirillo, Brodie J Hand, Wei-Yeh Liao, George M Opie, Ryoki Sasaki, John G Semmler
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引用次数: 0

摘要

经颅交流电刺激(tACS)在初级运动皮层(M1)已经被证明可以减少刺激期间γ -氨基丁酸(GABA)介导的抑制。然而,伽马tACS的有效性可能受到多种因素的影响,如刺激频率、电流强度和年龄。本研究的目的是研究在青年人和老年人的M1上以不同的频率和强度施加伽马tACS时,皮质运动性兴奋性和gaba介导的抑制是否受到影响。从18名年轻人和17名老年人的右手第一背骨间肌获得肌电图记录。采用单脉冲和配对脉冲经颅磁刺激引起的运动诱发电位(MEP)振幅,检测伽玛和假tACS期间皮质运动兴奋性和短间隔皮质内抑制(SICI)。Gamma tACS应用于三个频率(60 Hz, 75 Hz, 90 Hz)和三个电流强度(1.0 mA, 1.5 mA, 2.0 mA)。在青年人和老年人中,tACS期间的皮质运动兴奋性不受不同频率和强度的影响。gamma tACS期间SICI的调制是频率和强度依赖的,在75 Hz和1.5-2.0 mA时比假手术抑制更强,但两者都不受年龄的影响。这些发现与之前的研究形成对比,表明在gamma tACS期间SICI减少并不是一致的结果。需要进一步的研究,包括更大范围的频率和强度,以确定调节人类M1兴奋性和γ - tACS皮质内抑制的最佳剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of gamma transcranial alternating current stimulation frequency and intensity on motor cortex excitability in young and older adults.

Gamma transcranial alternating current stimulation (tACS) over primary motor cortex (M1) has been shown to reduce gamma-aminobutyric acid (GABA)-mediated inhibition during stimulation. However, the effectiveness of gamma tACS may be influenced by various factors, such as stimulation frequency, current intensity, and age. The aim of this study was to examine whether corticomotor excitability and GABA-mediated inhibition is influenced by gamma tACS when applied at different frequencies and intensities over M1 of young and older adults. Electromyographic recordings were obtained from the right hand first dorsal interosseous muscle of 18 young and 17 older adults. Motor-evoked potential (MEP) amplitudes elicited by single- and paired-pulse transcranial magnetic stimulation were used to examine corticomotor excitability and short-interval intracortical inhibition (SICI) during gamma and sham tACS. Gamma tACS was applied at three frequencies (60 Hz, 75 Hz, and 90 Hz) and three current intensities (1.0 mA, 1.5 mA, and 2.0 mA). Corticomotor excitability during tACS was not altered by the different gamma frequencies and intensities in young and older adults. Modulation of SICI during gamma tACS was both frequency- and intensity-dependent, with more inhibition than sham for 75 Hz and at 1.5-2.0 mA, but neither was influenced by age. These findings contrast with previous studies, showing that reduced SICI during gamma tACS is not a consistent outcome. Further investigation that includes a greater range of frequencies and intensities is needed to identify the optimal dose for modulating human M1 excitability and intracortical inhibition with gamma tACS.NEW & NOTEWORTHY Mid-gamma transcranial alternating current stimulation (tACS) may modulate primary motor cortex (M1) GABA-mediated inhibition in a frequency- and intensity-dependent manner in both healthy young and older adults. However, reduced intracortical inhibition during gamma tACS is not a consistent finding and further investigation is needed to better understand how gamma tACS influences human M1 function across age groups.

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来源期刊
Journal of neurophysiology
Journal of neurophysiology 医学-神经科学
CiteScore
4.80
自引率
8.00%
发文量
255
审稿时长
2-3 weeks
期刊介绍: The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.
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