纤毛驱动纤毛黏液清除的两相流体结构相互作用模型。

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-07-21 DOI:10.1080/10255842.2025.2535014

Kavin Vishnu, Karupppasamy Subburaj, Monika Colombo

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引用次数: 0

摘要

本研究通过建立一种新的两相流固相互作用模型来解决黏毛清除在呼吸系统健康中的关键作用。目的是模拟由纤毛运动驱动的真实粘液运输。该模型采用直接纤毛建模和卡鲁非牛顿黏液层流变学，结合了一种新的方法来规定纤毛跳动模式。两相流固相互作用模拟揭示了纤毛动力学和黏液特性如何相互作用以影响清除效率。这些发现强调了流固耦合和粘液流变学在复制生理运输中的重要性，为理解气道疾病和设计治疗干预提供了见解。

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A two-phase fluid structure interaction model of mucociliary clearance driven by cilium.

This study addresses the critical role of mucociliary clearance in respiratory health by developing a novel two-phase fluid-structure interaction model. The aim is to simulate realistic mucus transport driven by ciliary motion. Using direct cilia modeling and Carreau non-Newtonian rheology for the mucus layer, the model incorporates a new method for prescribing cilia beat patterns. Two-phase fluid-structure interaction simulations reveal how cilia dynamics and mucus properties interact to influence clearance efficiency. These findings highlight the importance of fluid-structure coupling and mucus rheology in replicating physiological transport, offering insights for understanding airway diseases and designing therapeutic interventions.

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.