{"title":"补充褪黑素可改善2型糖尿病大鼠的认知功能损伤","authors":"Azubuike Raphael Nwaji , Kenneth Chiedozie Oparaji , Chima Igwe , Esther Onyinyechi Igwe , Miracle Princess Okechukwu , Joyful Idimmachi Esinulo , Toochukwu Simon , Kingsley Godspower Ogbonna","doi":"10.1016/j.prerep.2025.100055","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a metabolic disorder facilitated by defective regulation of glucose and lipid metabolism. This glycemic fluctuation may be responsible for the alterations associated with diabetic brain.</div></div><div><h3>Aim</h3><div>The study aimed to investigate the impact of melatonin treatment on brain of alloxan-fructose-induced type 2 diabetic rat model.</div></div><div><h3>Materials and methods</h3><div>A single dose of alloxan (150 mg/kg, i.p.) was given to 14-day fructose solution (20 % w/v) pre-treated rats in drinking water. Rats with glucose levels above 200 mg/dL were classified as diabetic after three days post-induction. 20 rats were randomly assigned to four groups and treated as control, melatonin, diabetic untreated, and diabetic treated groups, respectively. Melatonin (10 mg/kg, p.o.) was given daily for 15 days after diabetic induction.</div></div><div><h3>Results</h3><div>Supplementation of diabetic rats with melatonin had an effect on the lipid profile by significantly decreasing TG and VLDL-c while no changes were observed in the TC, HDL-c and LDL-c. Melatonin also impacted neuroinflammatory markers by significantly (p < 0.05) decreasing the brain level of TNF-α and decreasing NO with no changes observed in the CRP levels of the treated rats. There was a significant (p < 0.05) increase in dopamine with no effect on serotonin levels. A protective effect against cognitive dysfunction is also shown by significantly increasing % alternation.</div></div><div><h3>Conclusion</h3><div>This study affirms the beneficial effects of melatonin in alloxan-fructose-induced type 2 diabetes by reducing lipid peroxidation, neuroinflammation, and improving cognitive functions. Thus, suggests that melatonin may be essential for defending the brain against cognitive alterations linked to DM.</div></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"4 ","pages":"Article 100055"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Melatonin supplementation improves impairment in cognitive function in type 2 diabetes-induced rats\",\"authors\":\"Azubuike Raphael Nwaji , Kenneth Chiedozie Oparaji , Chima Igwe , Esther Onyinyechi Igwe , Miracle Princess Okechukwu , Joyful Idimmachi Esinulo , Toochukwu Simon , Kingsley Godspower Ogbonna\",\"doi\":\"10.1016/j.prerep.2025.100055\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a metabolic disorder facilitated by defective regulation of glucose and lipid metabolism. This glycemic fluctuation may be responsible for the alterations associated with diabetic brain.</div></div><div><h3>Aim</h3><div>The study aimed to investigate the impact of melatonin treatment on brain of alloxan-fructose-induced type 2 diabetic rat model.</div></div><div><h3>Materials and methods</h3><div>A single dose of alloxan (150 mg/kg, i.p.) was given to 14-day fructose solution (20 % w/v) pre-treated rats in drinking water. Rats with glucose levels above 200 mg/dL were classified as diabetic after three days post-induction. 20 rats were randomly assigned to four groups and treated as control, melatonin, diabetic untreated, and diabetic treated groups, respectively. Melatonin (10 mg/kg, p.o.) was given daily for 15 days after diabetic induction.</div></div><div><h3>Results</h3><div>Supplementation of diabetic rats with melatonin had an effect on the lipid profile by significantly decreasing TG and VLDL-c while no changes were observed in the TC, HDL-c and LDL-c. Melatonin also impacted neuroinflammatory markers by significantly (p < 0.05) decreasing the brain level of TNF-α and decreasing NO with no changes observed in the CRP levels of the treated rats. There was a significant (p < 0.05) increase in dopamine with no effect on serotonin levels. A protective effect against cognitive dysfunction is also shown by significantly increasing % alternation.</div></div><div><h3>Conclusion</h3><div>This study affirms the beneficial effects of melatonin in alloxan-fructose-induced type 2 diabetes by reducing lipid peroxidation, neuroinflammation, and improving cognitive functions. Thus, suggests that melatonin may be essential for defending the brain against cognitive alterations linked to DM.</div></div>\",\"PeriodicalId\":101015,\"journal\":{\"name\":\"Pharmacological Research - Reports\",\"volume\":\"4 \",\"pages\":\"Article 100055\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950200425000291\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950200425000291","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Melatonin supplementation improves impairment in cognitive function in type 2 diabetes-induced rats
Background
Diabetes mellitus (DM) is a metabolic disorder facilitated by defective regulation of glucose and lipid metabolism. This glycemic fluctuation may be responsible for the alterations associated with diabetic brain.
Aim
The study aimed to investigate the impact of melatonin treatment on brain of alloxan-fructose-induced type 2 diabetic rat model.
Materials and methods
A single dose of alloxan (150 mg/kg, i.p.) was given to 14-day fructose solution (20 % w/v) pre-treated rats in drinking water. Rats with glucose levels above 200 mg/dL were classified as diabetic after three days post-induction. 20 rats were randomly assigned to four groups and treated as control, melatonin, diabetic untreated, and diabetic treated groups, respectively. Melatonin (10 mg/kg, p.o.) was given daily for 15 days after diabetic induction.
Results
Supplementation of diabetic rats with melatonin had an effect on the lipid profile by significantly decreasing TG and VLDL-c while no changes were observed in the TC, HDL-c and LDL-c. Melatonin also impacted neuroinflammatory markers by significantly (p < 0.05) decreasing the brain level of TNF-α and decreasing NO with no changes observed in the CRP levels of the treated rats. There was a significant (p < 0.05) increase in dopamine with no effect on serotonin levels. A protective effect against cognitive dysfunction is also shown by significantly increasing % alternation.
Conclusion
This study affirms the beneficial effects of melatonin in alloxan-fructose-induced type 2 diabetes by reducing lipid peroxidation, neuroinflammation, and improving cognitive functions. Thus, suggests that melatonin may be essential for defending the brain against cognitive alterations linked to DM.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
