The social ambivalence and disease model: Childhood trauma as an antecedent factor linking spousal ambivalence to inflammation.

Objective: Ambivalence in relationships is related to health-relevant biological outcomes. However, the antecedent processes that contribute to this association are unknown. The primary aim of this study was to test the prediction of the social ambivalence and disease model, which highlights the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to inflammation.

Method: A sample of 107 heterosexual couples who had been married for at least 10 years was recruited. Participants completed the social relationship index to assess spousal ambivalence and the Childhood Trauma Questionnaire. Blood was drawn to determine levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 as measures of inflammation.

Results: Consistent with the social ambivalence and disease model, there was a significant indirect effect in which childhood trauma was related to greater spousal ambivalence which in turn was associated with higher hs-CRP levels. No evidence for the statistical mediational model was found for interleukin-6.

Conclusions: These results highlight the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to hs-CRP. It also highlights potential pathways that might be targeted for interventions pending further work. (PsycInfo Database Record (c) 2025 APA, all rights reserved).