成人体重调整腰围指数与S-Klotho水平的关系:NHANES 2007-2016

IF 3.8 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Jingjing Chen, Qingyi Zeng, Li Liu, Yilan Li, Anning Wang, Yingqi Yi, Zhanglan Wang, Weihong Sun, Wei Zhou, Yun Ye, Wei Li
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引用次数: 0

摘要

体重调整腰围指数(WWI)是一种新的肥胖指标,比传统的身体质量指数(BMI)等指标更能反映身体脂肪的分布。然而,第一次世界大战与血清Klotho水平(一种衰老生物标志物)之间的联系尚不清楚。该研究涉及年龄在40至79岁之间的未怀孕成年人,他们有关于BMI、腰围(WC)和血清Klotho水平的综合数据。我们分析了来自NHANES的12809名年龄在40至79岁之间的参与者的数据。第一次世界大战的计算方法是将体重除以体重的平方根。参与者根据第一次世界大战的价值被分成四分之一。一个多元线性回归模型评估了第一次世界大战与血清Klotho水平之间的关系,并进行了人口统计学一致性的亚组分析。分析显示一战与血清Klotho水平呈显著负相关(β = - 24.75, 95% CI: - 24.84, - 24.66)。第一次世界大战最高四分位数的受试者血清Klotho水平低于最低四分位数的受试者(β = - 27.88, 95% CI: - 28.03, - 27.73)。这种负相关在所有亚组中都是一致的,包括年龄、性别、糖尿病状况、高血压状况和BMI类别。我们的研究结果表明,WWI与血清Klotho浓度之间存在显著的负相关,这表明WWI可能是识别加速衰老和相关代谢并发症高风险个体的实用临床指标。将WWI纳入常规评估可以帮助临床医生更好地与患有Klotho减少及其相关健康后果风险的患者联系起来,支持更有针对性的预防或干预策略。横断面设计排除了因果推理,潜在的混杂因素,如身体活动、饮食因素和药物使用没有完全考虑在内。需要进一步的纵向和机制研究来证实这些关联并阐明潜在的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007–2016

The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007–2016

The weight-adjusted waist index (WWI) is a new obesity metric that may better reflect body fat distribution than traditional measures like body mass index (BMI). However, the link between WWI and serum Klotho levels, an aging biomarker, is not well understood. The study involved non-pregnant adults aged 40 to 79 years who had comprehensive data regarding BMI, waist circumference (WC), and serum Klotho levels. We analyzed data from 12,809 participants aged 40 to 79 years from NHANES. WWI was calculated by dividing WC by the square root of body weight. Participants were categorized into quartiles based on WWI values. A multivariate linear regression model assessed the relationship between WWI and serum Klotho levels, with subgroup analyses for demographic consistency. The analysis showed a significant negative correlation between WWI and serum Klotho levels (β = −24.75, 95% CI: −24.84, −24.66). Participants in the highest WWI quartile had lower serum Klotho levels than those in the lowest quartile (β = −27.88, 95% CI: −28.03, −27.73). This negative association was consistent across all subgroups, including age, gender, diabetes status, hypertension status, and BMI categories. Our findings indicate a significant negative association between WWI and serum Klotho concentrations, suggesting that WWI may be a practical clinical indicator for identifying individuals at higher risk of accelerated aging and related metabolic complications. Incorporating WWI into routine assessments could help clinicians better associated with patients at risk for reduced Klotho and its associated health consequences, supporting more targeted prevention or intervention strategies. The cross-sectional design precludes causal inference, and potential confounders such as physical activity, dietary factors, and medication use were not fully accounted for. Further longitudinal and mechanistic studies are needed to confirm these associations and clarify underlying pathways.

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来源期刊
Food Science & Nutrition
Food Science & Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
5.10%
发文量
434
审稿时长
24 weeks
期刊介绍: Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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