Jingjing Chen, Qingyi Zeng, Li Liu, Yilan Li, Anning Wang, Yingqi Yi, Zhanglan Wang, Weihong Sun, Wei Zhou, Yun Ye, Wei Li
{"title":"成人体重调整腰围指数与S-Klotho水平的关系:NHANES 2007-2016","authors":"Jingjing Chen, Qingyi Zeng, Li Liu, Yilan Li, Anning Wang, Yingqi Yi, Zhanglan Wang, Weihong Sun, Wei Zhou, Yun Ye, Wei Li","doi":"10.1002/fsn3.70487","DOIUrl":null,"url":null,"abstract":"<p>The weight-adjusted waist index (WWI) is a new obesity metric that may better reflect body fat distribution than traditional measures like body mass index (BMI). However, the link between WWI and serum Klotho levels, an aging biomarker, is not well understood. The study involved non-pregnant adults aged 40 to 79 years who had comprehensive data regarding BMI, waist circumference (WC), and serum Klotho levels. We analyzed data from 12,809 participants aged 40 to 79 years from NHANES. WWI was calculated by dividing WC by the square root of body weight. Participants were categorized into quartiles based on WWI values. A multivariate linear regression model assessed the relationship between WWI and serum Klotho levels, with subgroup analyses for demographic consistency. The analysis showed a significant negative correlation between WWI and serum Klotho levels (<i>β</i> = −24.75, 95% CI: −24.84, −24.66). Participants in the highest WWI quartile had lower serum Klotho levels than those in the lowest quartile (<i>β</i> = −27.88, 95% CI: −28.03, −27.73). This negative association was consistent across all subgroups, including age, gender, diabetes status, hypertension status, and BMI categories. Our findings indicate a significant negative association between WWI and serum Klotho concentrations, suggesting that WWI may be a practical clinical indicator for identifying individuals at higher risk of accelerated aging and related metabolic complications. Incorporating WWI into routine assessments could help clinicians better associated with patients at risk for reduced Klotho and its associated health consequences, supporting more targeted prevention or intervention strategies. The cross-sectional design precludes causal inference, and potential confounders such as physical activity, dietary factors, and medication use were not fully accounted for. Further longitudinal and mechanistic studies are needed to confirm these associations and clarify underlying pathways.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 7","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70487","citationCount":"0","resultStr":"{\"title\":\"The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007–2016\",\"authors\":\"Jingjing Chen, Qingyi Zeng, Li Liu, Yilan Li, Anning Wang, Yingqi Yi, Zhanglan Wang, Weihong Sun, Wei Zhou, Yun Ye, Wei Li\",\"doi\":\"10.1002/fsn3.70487\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The weight-adjusted waist index (WWI) is a new obesity metric that may better reflect body fat distribution than traditional measures like body mass index (BMI). However, the link between WWI and serum Klotho levels, an aging biomarker, is not well understood. The study involved non-pregnant adults aged 40 to 79 years who had comprehensive data regarding BMI, waist circumference (WC), and serum Klotho levels. We analyzed data from 12,809 participants aged 40 to 79 years from NHANES. WWI was calculated by dividing WC by the square root of body weight. Participants were categorized into quartiles based on WWI values. A multivariate linear regression model assessed the relationship between WWI and serum Klotho levels, with subgroup analyses for demographic consistency. The analysis showed a significant negative correlation between WWI and serum Klotho levels (<i>β</i> = −24.75, 95% CI: −24.84, −24.66). Participants in the highest WWI quartile had lower serum Klotho levels than those in the lowest quartile (<i>β</i> = −27.88, 95% CI: −28.03, −27.73). This negative association was consistent across all subgroups, including age, gender, diabetes status, hypertension status, and BMI categories. Our findings indicate a significant negative association between WWI and serum Klotho concentrations, suggesting that WWI may be a practical clinical indicator for identifying individuals at higher risk of accelerated aging and related metabolic complications. Incorporating WWI into routine assessments could help clinicians better associated with patients at risk for reduced Klotho and its associated health consequences, supporting more targeted prevention or intervention strategies. The cross-sectional design precludes causal inference, and potential confounders such as physical activity, dietary factors, and medication use were not fully accounted for. Further longitudinal and mechanistic studies are needed to confirm these associations and clarify underlying pathways.</p>\",\"PeriodicalId\":12418,\"journal\":{\"name\":\"Food Science & Nutrition\",\"volume\":\"13 7\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70487\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science & Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70487\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science & Nutrition","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70487","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007–2016
The weight-adjusted waist index (WWI) is a new obesity metric that may better reflect body fat distribution than traditional measures like body mass index (BMI). However, the link between WWI and serum Klotho levels, an aging biomarker, is not well understood. The study involved non-pregnant adults aged 40 to 79 years who had comprehensive data regarding BMI, waist circumference (WC), and serum Klotho levels. We analyzed data from 12,809 participants aged 40 to 79 years from NHANES. WWI was calculated by dividing WC by the square root of body weight. Participants were categorized into quartiles based on WWI values. A multivariate linear regression model assessed the relationship between WWI and serum Klotho levels, with subgroup analyses for demographic consistency. The analysis showed a significant negative correlation between WWI and serum Klotho levels (β = −24.75, 95% CI: −24.84, −24.66). Participants in the highest WWI quartile had lower serum Klotho levels than those in the lowest quartile (β = −27.88, 95% CI: −28.03, −27.73). This negative association was consistent across all subgroups, including age, gender, diabetes status, hypertension status, and BMI categories. Our findings indicate a significant negative association between WWI and serum Klotho concentrations, suggesting that WWI may be a practical clinical indicator for identifying individuals at higher risk of accelerated aging and related metabolic complications. Incorporating WWI into routine assessments could help clinicians better associated with patients at risk for reduced Klotho and its associated health consequences, supporting more targeted prevention or intervention strategies. The cross-sectional design precludes causal inference, and potential confounders such as physical activity, dietary factors, and medication use were not fully accounted for. Further longitudinal and mechanistic studies are needed to confirm these associations and clarify underlying pathways.
期刊介绍:
Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.