由先天性黑素细胞痣引起的增殖性神经系统错构瘤1例报告。

IF 1.1 4区 医学 Q3 DERMATOLOGY
Aizlynn Anne J. Robledo, Yu-Hung Wu
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引用次数: 0

摘要

增殖性神经性错构瘤(PNH)是一种罕见的增殖性结节,是一种良性皮肤增生,伴黑素细胞、神经支持带和间质分化,发生在先天性或获得性黑素细胞痣内。我们报告一位38岁女性的病例,她在童年时期出现在右内侧鞋底的棕黑色斑块,并在过去的一年里在中心表现出快速的结节生长。组织学检查显示一个界限清晰的真皮结节,其特征是中心有纺锤形细胞随意增生,周围有先天性黑素细胞痣。S-100、SOX-10、HMB45、EMA、Glut-A和CD34的免疫组化染色显示中央结节的黑素细胞、神经周围和纤维分化,与PNH一致。Ki-67染色有丝分裂活性极低,PRAME染色阴性。准确的病理诊断是至关重要的,以保证病人的性质,这种变化的痣和排除黑色素瘤的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proliferative Neurocristic Hamartoma Arising From a Congenital Melanocytic Nevus: A Case Report

Proliferative neurocristic hamartoma (PNH), a rare variant of proliferative nodule, is a benign cutaneous proliferation with melanocytic, neurosustentacular, and mesenchymal differentiation that develops within a congenital or acquired melanocytic nevus. We report the case of a 38-year-old female who presented with a brownish-black plaque on the right medial sole that appeared during childhood and showed rapid nodular growth in the center over the past year. Histological examination revealed a well-demarcated dermal nodule characterized by spindle cell proliferation in a haphazard pattern in the center, with a congenital melanocytic nevus in the periphery. Immunohistochemical staining for S-100, SOX-10, HMB45, EMA, Glut-A, and CD34 demonstrated melanocytic, perineural, and fibrous differentiation in the central nodule, consistent with PNH. The mitotic activity was very low for the Ki-67 stain, and the PRAME stain was negative. Accurate pathological diagnosis is essential to reassure the patient of the nature of this changing mole and exclude the possibility of melanoma.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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