{"title":"由先天性黑素细胞痣引起的增殖性神经系统错构瘤1例报告。","authors":"Aizlynn Anne J. Robledo, Yu-Hung Wu","doi":"10.1111/cup.14847","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Proliferative neurocristic hamartoma (PNH), a rare variant of proliferative nodule, is a benign cutaneous proliferation with melanocytic, neurosustentacular, and mesenchymal differentiation that develops within a congenital or acquired melanocytic nevus. We report the case of a 38-year-old female who presented with a brownish-black plaque on the right medial sole that appeared during childhood and showed rapid nodular growth in the center over the past year. Histological examination revealed a well-demarcated dermal nodule characterized by spindle cell proliferation in a haphazard pattern in the center, with a congenital melanocytic nevus in the periphery. Immunohistochemical staining for S-100, SOX-10, HMB45, EMA, Glut-A, and CD34 demonstrated melanocytic, perineural, and fibrous differentiation in the central nodule, consistent with PNH. The mitotic activity was very low for the Ki-67 stain, and the PRAME stain was negative. Accurate pathological diagnosis is essential to reassure the patient of the nature of this changing mole and exclude the possibility of melanoma.</p>\n </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"622-626"},"PeriodicalIF":1.1000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Proliferative Neurocristic Hamartoma Arising From a Congenital Melanocytic Nevus: A Case Report\",\"authors\":\"Aizlynn Anne J. Robledo, Yu-Hung Wu\",\"doi\":\"10.1111/cup.14847\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Proliferative neurocristic hamartoma (PNH), a rare variant of proliferative nodule, is a benign cutaneous proliferation with melanocytic, neurosustentacular, and mesenchymal differentiation that develops within a congenital or acquired melanocytic nevus. We report the case of a 38-year-old female who presented with a brownish-black plaque on the right medial sole that appeared during childhood and showed rapid nodular growth in the center over the past year. Histological examination revealed a well-demarcated dermal nodule characterized by spindle cell proliferation in a haphazard pattern in the center, with a congenital melanocytic nevus in the periphery. Immunohistochemical staining for S-100, SOX-10, HMB45, EMA, Glut-A, and CD34 demonstrated melanocytic, perineural, and fibrous differentiation in the central nodule, consistent with PNH. The mitotic activity was very low for the Ki-67 stain, and the PRAME stain was negative. Accurate pathological diagnosis is essential to reassure the patient of the nature of this changing mole and exclude the possibility of melanoma.</p>\\n </div>\",\"PeriodicalId\":15407,\"journal\":{\"name\":\"Journal of Cutaneous Pathology\",\"volume\":\"52 10\",\"pages\":\"622-626\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cutaneous Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cup.14847\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Pathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cup.14847","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Proliferative Neurocristic Hamartoma Arising From a Congenital Melanocytic Nevus: A Case Report
Proliferative neurocristic hamartoma (PNH), a rare variant of proliferative nodule, is a benign cutaneous proliferation with melanocytic, neurosustentacular, and mesenchymal differentiation that develops within a congenital or acquired melanocytic nevus. We report the case of a 38-year-old female who presented with a brownish-black plaque on the right medial sole that appeared during childhood and showed rapid nodular growth in the center over the past year. Histological examination revealed a well-demarcated dermal nodule characterized by spindle cell proliferation in a haphazard pattern in the center, with a congenital melanocytic nevus in the periphery. Immunohistochemical staining for S-100, SOX-10, HMB45, EMA, Glut-A, and CD34 demonstrated melanocytic, perineural, and fibrous differentiation in the central nodule, consistent with PNH. The mitotic activity was very low for the Ki-67 stain, and the PRAME stain was negative. Accurate pathological diagnosis is essential to reassure the patient of the nature of this changing mole and exclude the possibility of melanoma.
期刊介绍:
Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.