针对额上回的加速间歇性θ - burst刺激对精神分裂症患者认知功能的影响：一项双盲、随机、假对照临床试验

IF 9.6 1区医学 Q1 NEUROSCIENCES

Biological Psychiatry Pub Date : 2025-07-11 DOI:10.1016/j.biopsych.2025.06.034

Xingjie Peng, Chuhan Song, Yuhan Su, Dongyu Kang, Yuyan Huang, Jingmei Xiao, Jingda Cai, Chuwei Chen, Ping Shao, Renrong Wu

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引用次数: 0

摘要

认知障碍是精神分裂症的核心症状，是导致预后不良的重要因素。然而，有效的治疗认知缺陷的方法仍然有限。针对额上回（SFG）的加速间歇性θ -burst刺激（aiTBS）是一种治疗精神分裂症认知障碍的有希望的干预手段，尽管证据仍然很少。方法：这项双盲、随机、假对照研究涉及66名精神分裂症患者，他们被随机分配接受30次（每天3次，连续10天）的主动（n = 33）或虚假（n = 33） aiTBS。认知改善使用matrix共识认知电池（MCCB）和额外的神经心理学测试进行评估。体素全脑功能连接和频谱动态连接建模也进行了评估。

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Effects of Accelerated Intermittent Theta-Burst Stimulation Targeting the Superior Frontal Gyrus on Cognitive Function in Patients with Schizophrenia: A Double-Blind, Randomized, Sham-Controlled Clinical Trial

Cognitive impairment is a core symptom of schizophrenia, significantly contributing to poor prognosis. However, effective treatments for cognitive deficits remain limited. Accelerated intermittent theta-burst stimulation (aiTBS) targeting the superior frontal gyrus (SFG) is a promising intervention for cognitive impairment in schizophrenia, though evidence remains scarce. Methods: This double-blind, randomized sham-controlled study involved 66 individuals with schizophrenia, who were randomly assigned to receive either active (n = 33) or sham (n = 33) aiTBS for 30 sessions (3 times daily for 10 consecutive days). Cognitive improvement was assessed using the MATRICS Consensus Cognitive Battery (MCCB) and additional neuropsychological tests. Voxel-wise whole-brain functional connectivity and spectral dynamic connectivity modelling were also evaluated.

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来源期刊

Biological Psychiatry 医学-精神病学

CiteScore

18.80

自引率

2.80%

发文量

1398

审稿时长

33 days

期刊介绍： Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.