尼古丁破坏了自上而下对腹侧被盖区胆碱能输入的控制，从而增加了食物奖励的动机价

IF 9.6 1区医学 Q1 NEUROSCIENCES

Biological Psychiatry Pub Date : 2025-07-12 DOI:10.1016/j.biopsych.2025.06.036

Renan C. Campos, Fabio Marti, Daiana Rigoni, Hugo Fofo, Paula Pousinha, Vanesa Ortiz, Léa Royon, Marion Violain, Nicolas Heck, Philippe Faure, Mariano Soiza-Reilly, Sebastian P. Fernandez, Jacques Barik

{"title":"尼古丁破坏了自上而下对腹侧被盖区胆碱能输入的控制，从而增加了食物奖励的动机价","authors":"Renan C. Campos, Fabio Marti, Daiana Rigoni, Hugo Fofo, Paula Pousinha, Vanesa Ortiz, Léa Royon, Marion Violain, Nicolas Heck, Philippe Faure, Mariano Soiza-Reilly, Sebastian P. Fernandez, Jacques Barik","doi":"10.1016/j.biopsych.2025.06.036","DOIUrl":null,"url":null,"abstract":"Tobacco use significantly impacts reward-driven behavior, leading to comorbidities across a lifetime. While the addictive properties of nicotine are well-studied, its effects on cellular mechanisms beyond drug-seeking behaviors remain elusive. Here we investigate the circuit alterations that parallel drug-related behaviors.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nicotine disrupts top down habenular control over cholinergic inputs to the ventral tegmental area to increase motivational valence of food rewards\",\"authors\":\"Renan C. Campos, Fabio Marti, Daiana Rigoni, Hugo Fofo, Paula Pousinha, Vanesa Ortiz, Léa Royon, Marion Violain, Nicolas Heck, Philippe Faure, Mariano Soiza-Reilly, Sebastian P. Fernandez, Jacques Barik\",\"doi\":\"10.1016/j.biopsych.2025.06.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tobacco use significantly impacts reward-driven behavior, leading to comorbidities across a lifetime. While the addictive properties of nicotine are well-studied, its effects on cellular mechanisms beyond drug-seeking behaviors remain elusive. Here we investigate the circuit alterations that parallel drug-related behaviors.\",\"PeriodicalId\":8918,\"journal\":{\"name\":\"Biological Psychiatry\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.biopsych.2025.06.036\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.biopsych.2025.06.036","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

烟草使用显著影响奖励驱动行为，导致一生的合并症。虽然尼古丁的成瘾性已经得到了充分的研究，但它对细胞机制的影响，除了寻求药物的行为之外，仍然难以捉摸。在这里，我们研究了与药物相关的行为并行的回路改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Nicotine disrupts top down habenular control over cholinergic inputs to the ventral tegmental area to increase motivational valence of food rewards

Tobacco use significantly impacts reward-driven behavior, leading to comorbidities across a lifetime. While the addictive properties of nicotine are well-studied, its effects on cellular mechanisms beyond drug-seeking behaviors remain elusive. Here we investigate the circuit alterations that parallel drug-related behaviors.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biological Psychiatry 医学-精神病学

CiteScore

18.80

自引率

2.80%

发文量

1398

审稿时长

33 days

期刊介绍： Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.