三种处理方法对开花白菜生物活性成分的影响。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-07-10 DOI:10.1002/jsfa.70044

Xuewei Xia, Guo Li, Wenshen Lin, Youhong Li, Xiaodan Chen, Qianmin Lin, Jiajing Zhen, Haichou Li, Supaluck Kraithong, Riming Huang, Xian Yang

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引用次数: 0

摘要

背景：开花白菜是一种受欢迎的芸苔属蔬菜，因其营养价值而受到重视。然而，常见的加工方法对其生物活性成分及其相关生物活性的影响仍未被探索。了解这些变化对于在消费和工业生产过程中最大限度地提高其健康效益至关重要。研究了蒸干、热风干燥和冷冻干燥三种典型处理方式对白菜中活性成分的影响。评价其甲醇提取物对结肠癌细胞株HT29增殖的抑制作用。使用非靶向代谢组学和网络药理学分析发现了导致所观察到的效果的成分变化和潜在的生物活性成分。结果：与蒸制组相比，热风干燥和冷冻干燥两种干燥方式在1000 μg mL-1时均能显著抑制HT29细胞的增殖。代谢组学分析显示，肉桂酸及其衍生物、黄酮类化合物和prenol脂质是三种加工方法显著改变的主要代谢产物类别。鉴于两种干燥组都具有较好的抑制活性，网络药理学分析确定了两种干燥组中富集的特定差异代谢物（萝卜硫素、喷他脒、s -腺苷同型半胱氨酸和s -腺苷蛋氨酸）可能是抗增殖的关键因素。结论：不同加工方法可显著改变白菜的生物活性成分及其抗癌潜力。特别是干燥过程，可以增强与HT29细胞抑制作用相关的特定生物活性代谢物。这些发现为选择加工方法来保存或增强这种蔬菜的健康促进特性提供了有价值的见解。©2025化学工业协会。

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Bioactive component shifts in flowering Chinese cabbage treated by three processing methods.

Background: Flowering Chinese cabbage is a popular Brassica vegetable valued for its nutritional properties. However, the impact of common processing methods on its bioactive components and their associated biological activities remains unexplored. Understanding these shifts is crucial for maximizing its health benefits during consumption and industrial production. This study investigated how the bioactive ingredients in flowering Chinese cabbage were impacted by three typical processing methods: steaming, hot-air drying, and freeze-drying. Their methanol extracts for preventing the proliferation of colon cancer cell line HT29 were assessed. Component shifts and potential bioactive components responsible for the observed effects were found using untargeted metabolomics and network pharmacology analysis.

Results: The results show that, in contrast to the steamed group, both drying methods (hot-air drying and freeze-drying) demonstrated significant inhibition of HT29 cell proliferation at 1000 μg mL^-1. Metabolomic analysis revealed that cinnamic acids and derivatives, flavonoids, and prenol lipids were the primary metabolite categories significantly altered by all three processing methods. Given the superior inhibitory activity of both drying groups, network pharmacology analysis pinpointed specific differential metabolites (sulforaphane, pentamidine, S-adenosylhomocysteine, and S-adenosylmethionine) enriched in both drying groups as potential key contributors to the anti-proliferative.

Conclusion: This study provides clear evidence that processing methods significantly alter the bioactive component profile and associated anti-cancer potential of flowering Chinese cabbage. Drying processes, in particular, enhance specific bioactive metabolites linked to potent HT29 cell inhibition. These findings offer valuable insights for selecting processing methods to preserve or enhance the health-promoting properties of this vegetable. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.