真菌生物聚合物纳米颗粒用于伤口愈合:机制、应用和未来展望

IF 5.1 Q1 CHEMISTRY, APPLIED
Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari
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引用次数: 0

摘要

真菌衍生的生物聚合物已经成为现有合成材料的一个有希望的替代品,并且由于其独特的特性,如耐久性,生物可降解性,生物相容性,低毒性,非免疫原性,以及与天然细胞外基质的相似性,在伤口愈合平台中获得了高度的兴趣。主要的真菌生物聚合物,如几丁质、壳聚糖、β-葡聚糖、甘露聚糖和普鲁兰,在伤口愈合方面提供了几种生物医学和临床优势,可以重塑受伤组织,使它们适合于加速伤口愈合的各个阶段。这些生物聚合物不仅支持细胞增殖、血管生成和组织重塑,而且还作为有效的药物递送载体,增强治疗药物的功效,加速伤口部位的细胞反应。该综述还概述了涉及伤口愈合各个阶段的生物学过程,为开发优化的伤口敷料的未来探索提供见解,以确保最大限度地减少炎症并允许皮肤调节。真菌介导的纳米颗粒和混合纳米复合材料通过提供更高的机械稳定性、生物相容性和靶向生物活性,进一步改善了伤口敷料的功能性能。总的来说,这些发现强调了真菌生物聚合物纳米颗粒作为一种新颖、可持续和有效的伤口处理方案的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives
Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.
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