Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari
{"title":"真菌生物聚合物纳米颗粒用于伤口愈合:机制、应用和未来展望","authors":"Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari","doi":"10.1016/j.fhfh.2025.100229","DOIUrl":null,"url":null,"abstract":"<div><div>Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100229"},"PeriodicalIF":5.1000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives\",\"authors\":\"Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari\",\"doi\":\"10.1016/j.fhfh.2025.100229\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.</div></div>\",\"PeriodicalId\":12385,\"journal\":{\"name\":\"Food Hydrocolloids for Health\",\"volume\":\"8 \",\"pages\":\"Article 100229\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Hydrocolloids for Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667025925000354\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hydrocolloids for Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667025925000354","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives
Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.