脂联素和细胞外囊泡促进健康的治疗潜力。

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-07-03 DOI:10.1016/j.arr.2025.102823

Yubin Lei , Hye Kyoung Sung , Dylan Burger , Gary Sweeney

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引用次数: 0

摘要

随着年龄的增长，生理功能的逐渐下降会导致一系列慢性疾病，如阿尔茨海默氏症、2型糖尿病、心力衰竭和骨关节炎。由于社会经济的发展，人类寿命的显著提高对全球医疗保健系统造成了可预见的巨大压力。事实上，现在的研究重点已经转向了延长健康寿命。因此，开发各种慢性病的改进疗法对于提高老龄化人口的健康寿命至关重要。脂联素主要产生于脂肪组织，在健康百岁老人的血液中含量较高。相反，较低的循环脂联素水平与一些年龄相关并发症的发生和严重程度呈负相关。在临床前模型中，脂联素在促进与衰老相关疾病相关的关键生物学过程的有益作用中起着至关重要的作用，有助于提高健康寿命和寿命。近年来，细胞外囊泡（EVs）因其在局部旁分泌信号和全身器官间通讯中的重要作用而引起了广泛的研究兴趣。它们作为有价值的诊断和治疗工具的潜力现已得到广泛认可。本文综述了脂联素和EVs在衰老过程中的病理生理作用，强调了它们在衰老相关疾病中的联合治疗潜力。此外，我们探索了脂联素和ev之间的串扰的新证据，强调了它们在制定促进健康衰老和长寿的改进策略方面的潜力。

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The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan

The gradual decline in physiological functions that comes with aging contributes to a range of chronic diseases, such as Alzheimer's, type 2 diabetes, heart failure, and osteoarthritis. Significant advancements in human longevity due to socioeconomic development have resulted in a foreseeable and substantial strain on the global healthcare system. In fact, there is now a shift in research focus towards enhancing healthspan. As a result, the development of improved therapies for various chronic diseases is essential to enhance healthspan in the aging population. Adiponectin, mainly produced in adipose tissue, is found at elevated levels in the blood of healthy centenarians. In contrast, lower circulating levels of adiponectin are inversely associated with the occurrence and severity of several age-related complications. Adiponectin plays a crucial role in promoting beneficial effects on key biological processes associated with aging-related diseases, contributing to improved healthspan and lifespan in preclinical models. In recent years, extracellular vesicles (EVs) have garnered significant research interest due to their crucial role in both local paracrine signaling and systemic inter-organ communication. They are now widely recognized for their potential as valuable diagnostic and therapeutic tools. In this review, we summarize current knowledge on the pathophysiological roles of adiponectin and EVs in aging, emphasizing their combined therapeutic potential in age-related diseases. Additionally, we explore the emerging evidence of crosstalk between adiponectin and EVs, underscoring their potential for developing improved strategies to promote healthy aging and longevity.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.