骨免疫学和衰老：机制、意义和治疗观点。

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-07-01 DOI:10.1016/j.arr.2025.102822

Yu-tong Wang , Sheng-yuan Zheng , Yan Luo , Wen-feng Xiao , Cheng Huang , Yu-sheng Li

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引用次数: 0

摘要

骨免疫学是一门研究免疫系统与骨骼系统相互作用的交叉学科，旨在揭示影响骨骼健康和疾病的免疫调节机制。衰老是一个宏观的概念，它不仅限于细胞的衰老，还包括整个身体的衰老。研究表明，衰老可通过影响骨髓微环境、引起免疫细胞功能障碍、引发炎症反应、破坏骨稳态等多种机制影响骨免疫功能，导致骨病的发生。因此，本文对骨免疫学的相关细胞和机制进行了全面的介绍，详细阐述了免疫细胞和骨细胞衰老的特点、骨细胞和免疫细胞之间的相互影响以及衰老对骨免疫功能的影响。在此基础上，我们对急性髓系白血病、类风湿关节炎、骨质疏松症和牙周炎的衰老机制和骨免疫发病机制提出了新的见解，并提出了抗衰老治疗骨免疫相关疾病的策略，为骨免疫相关疾病的治疗提供了新的思路。

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Osteoimmunology and aging: Mechanisms, implications, and therapeutic perspectives

Osteoimmunology is an interdisciplinary study of the interaction between the immune system and the skeletal system, aiming to reveal the immune regulation mechanisms that affect bone health and disease. Aging is a macro concept, which is not limited to the senescence of cells, but also includes the aging of the body as a whole. Studies have shown that aging can affect osteoimmune function through various mechanisms such as affecting the bone marrow microenvironment, causing immune cell dysfunction, triggering inflammatory responses, and destroying bone homeostasis, leading to the occurrence of bone diseases. Therefore, this review provides a comprehensive introduction to the related cells and mechanisms of osteoimmunology, elaborating in detail the characteristics of senescence of immune cells and bone cells, the mutual influences between bone cells and immune cells and the impact of aging on osteoimmune function. On this basis, we propose new insights on the mechanisms of aging and osteoimmune pathogenesis in Acute myeloid leukemia, Rheumatoid Arthritis, Osteoporosis and Periodontitis, and propose anti-aging strategies for the treatment of osteoimmune-related diseases, which provides a new idea for the treatment of osteoimmune-related diseases.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.