饮酒导致的全球乳腺癌负担：多区域观察性分析（1990-2021年）

IF 3.6 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2025-07-03 DOI:10.1016/j.addbeh.2025.108426

Fangfang Cui , Yuntian Chu , Weiyi Wang , Meihao Ji , Sidong Zhang , Zhengyu Wu , Yadong Song

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引用次数: 0

摘要

乳腺癌是世界范围内女性的主要恶性肿瘤，饮酒是一个重要的可改变的危险因素。然而，不同地区因饮酒导致的乳腺癌负担尚未得到充分评估。本研究旨在量化1990年至2021年各地区因饮酒导致的全球乳腺癌负担，并分析其演变趋势，为有效的干预策略提供信息。方法该研究利用全球疾病负担（GBD）数据评估1990年至2021年不同性别、年龄组和地区的乳腺癌死亡率和残疾调整生命年（DALYs）。分析的重点是酒精使用对乳腺癌负担的影响，特别关注不同社会人口指数（SDI）水平的区域，使用年龄标准化死亡率（ASMR）和伤残调整生命年。从1990年到2021年，全球因酒精导致的乳腺癌死亡人数从14,980人增加到18,760人，而ASMR从每10万人0.38人下降到0.22人。高sdi地区的死亡率显著下降（年下降1.62%），而低sdi地区的死亡率则有所上升。50岁以上妇女的疾病负担最高，特别是在大洋洲、西欧和拉丁美洲南部。虽然男性的负担较低，但死亡率呈上升趋势。结论：该研究强调，在高sdi地区，酒精导致的乳腺癌负担有所下降，但在低sdi地区，这一负担继续上升。需要有针对性的公共卫生干预措施和战略，以减少酒精消费和相关的乳腺癌负担。

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Global burden of breast cancer attributable to alcohol consumption: a multi-regional observational analysis (1990–2021)

Background

Breast cancer is a leading malignancy among women worldwide, with alcohol consumption being a significant modifiable risk factor. However, the burden of breast cancer attributable to alcohol consumption across different regions has not been fully assessed.

Aims

This study aims to quantify the global burden of breast cancer due to alcohol consumption from 1990 to 2021 across various regions, and analyze the evolving trends to inform effective intervention strategies.

Methods

The study utilized Global Burden of Disease (GBD) data to assess breast cancer mortality and Disability-Adjusted Life Years (DALYs) across different genders, age groups, and regions from 1990 to 2021. The analysis focused on the impact of alcohol use on breast cancer burden, with particular attention to regions with varying Socio-Demographic Index (SDI) levels, using Age-Standardized Mortality Rates (ASMR) and DALYs.

Results

From 1990 to 2021, global deaths from alcohol-attributable breast cancer increased from 14,980 to 18,760, while the ASMR decreased from 0.38 to 0.22 per 100,000. High-SDI regions experienced a significant decline in mortality (annual decrease of 1.62 %), whereas low-SDI regions saw an increase. Women over 50 years old had the highest disease burden, particularly in Australasia, Western Europe, and Southern Latin America. Although the burden is lower in men, their mortality showed an upward trend.

Conclusions

The study highlights that while the burden of alcohol-attributable breast cancer has decreased in high-SDI regions, it continues to rise in low-SDI regions. Targeted public health interventions and strategies, are needed to reduce alcohol consumption and the associated breast cancer burden.

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.