{"title":"探索咖啡消费和咖啡因摄入对老年人认知表现的影响：使用NHANES数据和基因相关分析的综合分析。","authors":"Jinrui Li, Kai Yu, Fan Bu, Peng Li, Lei Hao","doi":"10.1186/s12937-025-01173-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of coffee consumption and caffeine intake on cognitive performance in older adults, with a particular focus on the potential mediating role of alkaline phosphatase(ALP).</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, involving 2,254 participants aged 60 and older. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). To establish causal relationships between coffee consumption, caffeine intake, ALP levels, and cognitive performance, we employed methodologies such as Mendelian randomization, protein quantitative trait locus analysis, and protein-protein interaction networks.</p><p><strong>Results: </strong>The NHANES study revealed significant findings regarding coffee consumption and cognitive performance. Compared to non-coffee consumers, individuals consuming ≥ 480 g/day of coffee had a significantly lower odds of low CERAD scores, with an adjusted OR of 0.58 (95% CI: 0.41-0.82) in the fully adjusted Model 4. Similarly, those consuming caffeinated coffee 477.9 g/day) had an OR of 0.56 (95% CI: 0.34-0.92). A comparison of the lowest quartile of ALP intake with the highest quartile showed an OR of 1.82 (95% CI: 1.16-2.85), indicating a negative correlation with cognitive performance. Mendelian Randomization (MR) studies suggested that increased coffee intake is associated with cognitive impairment progression, while coffee consumption may protect against Lewy body dementia (OR = 0.2365, 95% CI: 0.0582-0.9610). Additionally, coffee/caffeine intake affected serum ALP (OR = 0.86, 95% CI: 0.79-0.93) and cognitive ability (OR = 0.95, 95% CI: 0.92-0.98), both indicating protective effects. Finally, the IGFLR1 gene exhibited a moderate colocalization with ALP, suggesting potential therapeutic significance.</p><p><strong>Conclusions: </strong>This study provides evidence of a positive correlation between coffee consumption, caffeine intake, and cognitive performance in older adults, with ALP potentially contributing to this relationship. These findings underscore the importance of considering dietary factors in cognitive health management for aging populations, highlighting the need for further research to clarify the specific mechanisms involved.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"102"},"PeriodicalIF":3.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220005/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.\",\"authors\":\"Jinrui Li, Kai Yu, Fan Bu, Peng Li, Lei Hao\",\"doi\":\"10.1186/s12937-025-01173-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the effects of coffee consumption and caffeine intake on cognitive performance in older adults, with a particular focus on the potential mediating role of alkaline phosphatase(ALP).</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, involving 2,254 participants aged 60 and older. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). To establish causal relationships between coffee consumption, caffeine intake, ALP levels, and cognitive performance, we employed methodologies such as Mendelian randomization, protein quantitative trait locus analysis, and protein-protein interaction networks.</p><p><strong>Results: </strong>The NHANES study revealed significant findings regarding coffee consumption and cognitive performance. Compared to non-coffee consumers, individuals consuming ≥ 480 g/day of coffee had a significantly lower odds of low CERAD scores, with an adjusted OR of 0.58 (95% CI: 0.41-0.82) in the fully adjusted Model 4. Similarly, those consuming caffeinated coffee 477.9 g/day) had an OR of 0.56 (95% CI: 0.34-0.92). A comparison of the lowest quartile of ALP intake with the highest quartile showed an OR of 1.82 (95% CI: 1.16-2.85), indicating a negative correlation with cognitive performance. Mendelian Randomization (MR) studies suggested that increased coffee intake is associated with cognitive impairment progression, while coffee consumption may protect against Lewy body dementia (OR = 0.2365, 95% CI: 0.0582-0.9610). Additionally, coffee/caffeine intake affected serum ALP (OR = 0.86, 95% CI: 0.79-0.93) and cognitive ability (OR = 0.95, 95% CI: 0.92-0.98), both indicating protective effects. Finally, the IGFLR1 gene exhibited a moderate colocalization with ALP, suggesting potential therapeutic significance.</p><p><strong>Conclusions: </strong>This study provides evidence of a positive correlation between coffee consumption, caffeine intake, and cognitive performance in older adults, with ALP potentially contributing to this relationship. These findings underscore the importance of considering dietary factors in cognitive health management for aging populations, highlighting the need for further research to clarify the specific mechanisms involved.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":19203,\"journal\":{\"name\":\"Nutrition Journal\",\"volume\":\"24 1\",\"pages\":\"102\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220005/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12937-025-01173-x\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-025-01173-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.
Purpose: To investigate the effects of coffee consumption and caffeine intake on cognitive performance in older adults, with a particular focus on the potential mediating role of alkaline phosphatase(ALP).
Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, involving 2,254 participants aged 60 and older. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). To establish causal relationships between coffee consumption, caffeine intake, ALP levels, and cognitive performance, we employed methodologies such as Mendelian randomization, protein quantitative trait locus analysis, and protein-protein interaction networks.
Results: The NHANES study revealed significant findings regarding coffee consumption and cognitive performance. Compared to non-coffee consumers, individuals consuming ≥ 480 g/day of coffee had a significantly lower odds of low CERAD scores, with an adjusted OR of 0.58 (95% CI: 0.41-0.82) in the fully adjusted Model 4. Similarly, those consuming caffeinated coffee 477.9 g/day) had an OR of 0.56 (95% CI: 0.34-0.92). A comparison of the lowest quartile of ALP intake with the highest quartile showed an OR of 1.82 (95% CI: 1.16-2.85), indicating a negative correlation with cognitive performance. Mendelian Randomization (MR) studies suggested that increased coffee intake is associated with cognitive impairment progression, while coffee consumption may protect against Lewy body dementia (OR = 0.2365, 95% CI: 0.0582-0.9610). Additionally, coffee/caffeine intake affected serum ALP (OR = 0.86, 95% CI: 0.79-0.93) and cognitive ability (OR = 0.95, 95% CI: 0.92-0.98), both indicating protective effects. Finally, the IGFLR1 gene exhibited a moderate colocalization with ALP, suggesting potential therapeutic significance.
Conclusions: This study provides evidence of a positive correlation between coffee consumption, caffeine intake, and cognitive performance in older adults, with ALP potentially contributing to this relationship. These findings underscore the importance of considering dietary factors in cognitive health management for aging populations, highlighting the need for further research to clarify the specific mechanisms involved.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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