Victor A de Vries, Karin A van Garderen, Caroline C W Klaver, Daniel Bos, Maryam Kavousi, Wishal D Ramdas
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Linear and logistic regressions were used to analyze within participants with OAG the effect of cIMT on age at diagnosis and the requirement for glaucoma surgery.</p><p><strong>Results: </strong>Among 9652 participants, 193 developed OAG during 89,665 person-years of follow-up (mean follow-up = 10.5 years). Each standard deviation increase in cIMT was associated with a 17% higher risk of developing OAG (adjusted hazard ratio = 1.17, 95% confidence interval [CI] = 1.00 to 1.36, P = 0.047). Although no association between cIMT and IOP was found, the mRNFL thickness decreased by an average of 0.17 µm (95% CI = 0.01 to 0.34) for each standard deviation increase in cIMT. Among participants with OAG, an increased cIMT was also associated with a younger age at diagnosis (beta = -1.01 years, 95% CI = -1.84 to -0.17), and more frequent requirement of glaucoma surgery (odds ratio [OR] = 1.93, 95% CI = 1.07 to 3.50).</p><p><strong>Conclusions: </strong>Among participants with OAG, an increased cIMT was associated with a younger age at diagnosis. In patients with OAG and unexplained continuous progression, a screening ultrasound examination of the carotid arteries might be considered.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 9","pages":"9"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227022/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma.\",\"authors\":\"Victor A de Vries, Karin A van Garderen, Caroline C W Klaver, Daniel Bos, Maryam Kavousi, Wishal D Ramdas\",\"doi\":\"10.1167/iovs.66.9.9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>There is evidence that patients with open-angle glaucoma (OAG) have altered hemodynamic parameters of the carotid and retinal arteries. We investigated the effect of carotid artery atherosclerosis on incident OAG, intraocular pressure (IOP), and macular retinal nerve fiber layer (mRNFL) in the general population.</p><p><strong>Methods: </strong>We analyzed data from the Rotterdam Study, a large prospective population-based cohort study. Carotid atherosclerosis was assessed by measuring the carotid intima-media thickness (cIMT). We used multivariable Cox proportional hazard models to estimate the effect of cIMT on OAG risk, and linear mixed models for IOP and mRNFL. Linear and logistic regressions were used to analyze within participants with OAG the effect of cIMT on age at diagnosis and the requirement for glaucoma surgery.</p><p><strong>Results: </strong>Among 9652 participants, 193 developed OAG during 89,665 person-years of follow-up (mean follow-up = 10.5 years). Each standard deviation increase in cIMT was associated with a 17% higher risk of developing OAG (adjusted hazard ratio = 1.17, 95% confidence interval [CI] = 1.00 to 1.36, P = 0.047). Although no association between cIMT and IOP was found, the mRNFL thickness decreased by an average of 0.17 µm (95% CI = 0.01 to 0.34) for each standard deviation increase in cIMT. Among participants with OAG, an increased cIMT was also associated with a younger age at diagnosis (beta = -1.01 years, 95% CI = -1.84 to -0.17), and more frequent requirement of glaucoma surgery (odds ratio [OR] = 1.93, 95% CI = 1.07 to 3.50).</p><p><strong>Conclusions: </strong>Among participants with OAG, an increased cIMT was associated with a younger age at diagnosis. 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引用次数: 0
摘要
目的:有证据表明开角型青光眼(OAG)患者的颈动脉和视网膜动脉的血流动力学参数发生了改变。我们研究了颈动脉粥样硬化对普通人群OAG、眼内压(IOP)和黄斑视网膜神经纤维层(mRNFL)的影响。方法:我们分析了鹿特丹研究的数据,这是一项大型前瞻性人群队列研究。通过测量颈动脉内膜-中膜厚度(cIMT)评估颈动脉粥样硬化。我们使用多变量Cox比例风险模型来评估cIMT对OAG风险的影响,并使用线性混合模型来评估IOP和mRNFL。使用线性和逻辑回归分析OAG参与者中cIMT对诊断年龄和青光眼手术需求的影响。结果:9652名参与者中,有193名在89,665人-年的随访期间(平均随访= 10.5年)发生了OAG。cIMT每增加一个标准差,发生OAG的风险增加17%(校正风险比= 1.17,95%可信区间[CI] = 1.00 ~ 1.36, P = 0.047)。虽然cIMT和IOP之间没有关联,但cIMT每增加一个标准差,mRNFL厚度平均减少0.17µm (95% CI = 0.01 ~ 0.34)。在OAG患者中,cIMT的增加还与诊断年龄较年轻(β = -1.01岁,95% CI = -1.84至-0.17)和青光眼手术的频繁要求相关(优势比[OR] = 1.93, 95% CI = 1.07至3.50)。结论:在OAG的参与者中,cIMT的增加与诊断年龄的年轻有关。对于OAG和不明原因的持续进展的患者,可以考虑进行颈动脉超声筛查检查。
The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma.
Purpose: There is evidence that patients with open-angle glaucoma (OAG) have altered hemodynamic parameters of the carotid and retinal arteries. We investigated the effect of carotid artery atherosclerosis on incident OAG, intraocular pressure (IOP), and macular retinal nerve fiber layer (mRNFL) in the general population.
Methods: We analyzed data from the Rotterdam Study, a large prospective population-based cohort study. Carotid atherosclerosis was assessed by measuring the carotid intima-media thickness (cIMT). We used multivariable Cox proportional hazard models to estimate the effect of cIMT on OAG risk, and linear mixed models for IOP and mRNFL. Linear and logistic regressions were used to analyze within participants with OAG the effect of cIMT on age at diagnosis and the requirement for glaucoma surgery.
Results: Among 9652 participants, 193 developed OAG during 89,665 person-years of follow-up (mean follow-up = 10.5 years). Each standard deviation increase in cIMT was associated with a 17% higher risk of developing OAG (adjusted hazard ratio = 1.17, 95% confidence interval [CI] = 1.00 to 1.36, P = 0.047). Although no association between cIMT and IOP was found, the mRNFL thickness decreased by an average of 0.17 µm (95% CI = 0.01 to 0.34) for each standard deviation increase in cIMT. Among participants with OAG, an increased cIMT was also associated with a younger age at diagnosis (beta = -1.01 years, 95% CI = -1.84 to -0.17), and more frequent requirement of glaucoma surgery (odds ratio [OR] = 1.93, 95% CI = 1.07 to 3.50).
Conclusions: Among participants with OAG, an increased cIMT was associated with a younger age at diagnosis. In patients with OAG and unexplained continuous progression, a screening ultrasound examination of the carotid arteries might be considered.
期刊介绍:
Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.