阿片类药物使用障碍住院治疗期间的睡眠中断、压力和渴望

IF 3.6 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2025-07-02 DOI:10.1016/j.addbeh.2025.108427

Juliette A. Bichon , Allen J. Bailey , Victoria R. Votaw , R. Kathryn McHugh

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引用次数: 0

摘要

睡眠障碍与阿片类药物滥用之间存在双向关系，阿片类药物使用障碍（OUD）患者经常经历睡眠不良和失眠。我们的目的是在寻求住院戒毒的OUD患者中描述睡眠、渴望和负面影响之间的关系。方法84例因OUD接受住院稳定和戒毒治疗的成年人完成了睡眠自我报告和标准化应激诱导（计算机镜像追踪持续性任务），并对他们的阿片类药物渴望和负面影响进行了前应激源和后应激源评估。我们研究了前一晚的睡眠和过去两周的失眠是否与情绪压力反应和压力引起的渴望有关。结果参与者报告说，他们在前两周失眠程度很高，而且比建议的睡眠时间短。睡眠特征与基线渴望和压力前负面影响之间没有显著关联。在过去的两周内，严重的失眠与压力引起的渴望和负面情绪有关，而昨晚的睡眠时间则与此无关。持续两周的失眠，而不是整夜的睡眠，与压力后的渴望和负面情绪增加有关，这表明睡眠紊乱可能是早期恢复的一个重要风险因素。为了更好地理解这些关联及其对复发和恢复的影响，需要用客观的睡眠测量方法进行复制和扩展。

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Sleep disruption, stress, and craving during inpatient treatment for opioid use disorder

Background

There is a bidirectional relationship between sleep disturbances and opioid misuse, and individuals with opioid use disorder (OUD) often experience poor sleep and insomnia. We aimed to characterize the relationship between sleep, craving, and negative affect among individuals with OUD seeking inpatient detoxification.

Methods

Adults receiving inpatient stabilization and detoxification treatment for OUD (N = 84) completed self-report measures of sleep and a standardized stress induction (the Computerized Mirror-Tracing Persistence Task) and rated their opioid craving and negative affect pre- and post-stressor. We examined whether sleep in the prior night and past two-week insomnia were associated with emotional stress reactivity and stress-induced craving.

Results

Participants reported high levels of insomnia in the prior two weeks and shorter than recommended prior night sleep duration. There were no significant associations between sleep characteristics and baseline craving and pre-stressor negative affect. Greater insomnia severity in the past two weeks was associated with greater stress-induced craving and negative affect, past-night sleep duration was not.

Discussion

Insomnia over a two-week period, but not past-night sleep, was associated with increased craving and negative affect following stress, suggesting that disturbed sleep may be an important risk factor in early recovery. Replication and extension with objective measures of sleep will be needed to better understand these associations and their impact on relapse and recovery.

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.