氧化应激、肠道细菌和微藻:一种管理炎症性肠病的整体方法。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shani Shoham, Noam Pintel, Dorit Avni
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引用次数: 0

摘要

氧化应激是炎症性肠病(IBD)病理生理的一个公认的贡献者,加剧了慢性炎症和组织损伤。虽然传统的IBD治疗主要侧重于免疫调节,但解决氧化应激和促进肠道微生物健康的替代方法为症状缓解和疾病管理提供了新的机会。微藻以其强大的抗氧化、抗炎和益生元特性而闻名,在减轻氧化损伤和支持有益的肠道细菌方面表现出了希望。这篇综述探讨了氧化应激在IBD中的多方面作用,并强调了微藻衍生化合物的治疗潜力。此外,它还研究了微藻抗氧化剂与益生菌结合以促进肠道稳态的协同效益。递送系统的进展,包括纳米技术和共生细菌-微藻相互作用,也作为靶向治疗的新兴方法进行了讨论。该综述最后确定了未来的研究重点,重点是临床转化和基于微藻的生物工程创新,以提高治疗IBD患者的疗效和可及性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases.

Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, known for their potent antioxidant, anti-inflammatory, and prebiotic properties, show promise in alleviating oxidative damage and supporting beneficial gut bacteria. This review explores the multifaceted role of oxidative stress in IBD and highlights the therapeutic potential of microalgae-derived compounds. In addition, it examines the synergistic benefits of combining microalgal antioxidants with probiotics to promote gut homeostasis. Advances in delivery systems, including nanotechnology and symbiotic bacteria-microalgae interactions, are also discussed as emerging approaches for targeted treatment. The review concludes by identifying future research priorities focused on clinical translation and microalgae-based bioengineering innovations to enhance the efficacy and accessibility of therapeutics for IBD patients.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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