菊粉可以改善饲粮中含有推荐铜纳米颗粒(CuNPs)水平的大鼠的氧化还原反应,而果胶或车前草在饲粮中摄入过量的铜纳米颗粒。

IF 6.6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aleksandra Marzec, Ewelina Cholewińska, Bartosz Fotschki, Jerzy Juśkiewicz, Katarzyna Ognik
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引用次数: 0

摘要

本研究旨在确定饲粮中添加推荐水平(6.5 mg Cu/kg日粮)或两倍推荐水平(13.0 mg Cu/kg日粮)的铜纳米颗粒(CuNPs)与不同类型的膳食纤维结合对雄性Wistar大鼠血液和组织中选定氧化还原状态指标的影响。对照组饲喂含有纤维素和矿物质混合物的饲粮,CuCO3含量达到标准或提高。试验组饲粮中分别添加6.5或13 mg/kg的CuNPs,并与纤维素、果胶、菊粉或车前草等不同类型的纤维结合。饲喂期结束后,收集大鼠的器官,评估氧化还原状态的选定指标。所获得的结果表明,在推荐剂量的CuNPs营养条件下,添加菊粉形式的膳食纤维可能有益地刺激氧化还原系统的反应,在饮食中过量供应CuNPs的情况下,添加果胶或车前草。因此,根据饮食中CuNPs的水平选择适当类型的膳食纤维可以有效地保护生物体免受CuNPs潜在的有害的促氧化作用,最终有助于对其在体内的代谢影响进行有利的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inulin Improves the Redox Response in Rats Fed a Diet Containing Recommended Copper Nanoparticle (CuNPs) Levels, While Pectin or Psyllium in Rats Receive Excessive CuNPs Levels in the Diet.

The study aimed to determine the effect of dietary inclusion of the recommended (6.5 mg Cu/kg diet) or double the recommended (13.0 mg Cu/kg diet) levels of copper nanoparticles (CuNPs) in combination with different types of dietary fibre on selected redox status indicators in the blood and tissues of male Wistar rats. Control groups were fed diets containing cellulose and a mineral mixture with standard or enhanced content of CuCO3. The experimental groups were fed a diet supplemented with CuNPs (6.5 or 13 mg/kg) and combined with various fibre types-cellulose, pectin, inulin, or psyllium. After the feeding period, rats' organs were collected to assess selected indicators of redox status. The obtained results suggest that the addition of dietary fibre in the form of inulin may beneficially stimulate the response of the redox system in the conditions of CuNPs nutrition at the recommended dose, pectin, or psyllium in the case of an excessive supply of CuNPs in the diet. Thus, selecting the appropriate type of dietary fibre based on the CuNPs' level in the diet may effectively protect the organism from the potentially harmful prooxidative effect of CuNPs, ultimately contributing to a favourable regulation of their metabolic impact in the body.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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