Florinda Fratianni, Francesca Coppola, Siria Tavaniello, Maria Neve Ombra, Beatrice De Giulio, Nunzio D'Agostino, Gokhan Zengin, Raffaele Coppola, Filomena Nazzaro
{"title":"琉璃苣、甘蓝和刺梨籽油的脂肪酸谱和一些有用的生物学方面:对健康和饮食使用的影响。","authors":"Florinda Fratianni, Francesca Coppola, Siria Tavaniello, Maria Neve Ombra, Beatrice De Giulio, Nunzio D'Agostino, Gokhan Zengin, Raffaele Coppola, Filomena Nazzaro","doi":"10.3390/antiox14060661","DOIUrl":null,"url":null,"abstract":"<p><p>Seed oils from <i>Borago officinalis</i> (borage), <i>Opuntia ficus-indica</i> (prickly pear), and <i>Calophyllum inophyllum</i> (calophyllum or tamanu) are rich in bioactive fatty acids and have been traditionally used in cosmetic and industrial sectors. This study explored their fatty acid composition and investigated their in vitro antioxidant, anti-arthritic, neuroprotective, and antibiofilm activities. Fatty acid profiles were determined via gas chromatography. Antioxidant activity was assessed using DPPH and ABTS radical scavenging assays. Anti-arthritic potential was measured via bovine serum albumin denaturation. Neuroprotective properties were evaluated through acetylcholinesterase, butirylcholinesterase, and tyrosinase inhibition. Antibiofilm activity against five pathogenic strains was analyzed using crystal violet and MTT assays. Correlation analysis was used to associate fatty acid composition with bioactivity. Prickly pear oil exhibited the highest PUFA content (65.1%), mainly linoleic acid. Calophyllum oil was richer in saturated and monounsaturated fatty acids. All oils showed significant radical scavenging ability, with calophyllum oil showing the lowest DPPH IC<sub>50</sub> and borage oil, the highest ABTS activity. Borage and prickly pear oils demonstrated strong anti-arthritic potential. Calophyllum oil showed the most potent AChE inhibition. All oils showed tyrosinase inhibition; however, calophyllum did not show BChE inhibitory activity. Antibiofilm activity was species- and dose-dependent, with <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Acinetobacter baumannii</i> being most affected. Thus, the tested oils exhibited multiple biological activities, influenced by their fatty acid composition. The in vitro antioxidant, anti-arthritic, neuroprotective, and antimicrobial properties support their potential use as functional food ingredients or nutraceuticals, especially for aging-related health concerns. Further in vivo and clinical studies are needed to confirm their efficacy.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189715/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.\",\"authors\":\"Florinda Fratianni, Francesca Coppola, Siria Tavaniello, Maria Neve Ombra, Beatrice De Giulio, Nunzio D'Agostino, Gokhan Zengin, Raffaele Coppola, Filomena Nazzaro\",\"doi\":\"10.3390/antiox14060661\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Seed oils from <i>Borago officinalis</i> (borage), <i>Opuntia ficus-indica</i> (prickly pear), and <i>Calophyllum inophyllum</i> (calophyllum or tamanu) are rich in bioactive fatty acids and have been traditionally used in cosmetic and industrial sectors. This study explored their fatty acid composition and investigated their in vitro antioxidant, anti-arthritic, neuroprotective, and antibiofilm activities. Fatty acid profiles were determined via gas chromatography. Antioxidant activity was assessed using DPPH and ABTS radical scavenging assays. Anti-arthritic potential was measured via bovine serum albumin denaturation. Neuroprotective properties were evaluated through acetylcholinesterase, butirylcholinesterase, and tyrosinase inhibition. Antibiofilm activity against five pathogenic strains was analyzed using crystal violet and MTT assays. Correlation analysis was used to associate fatty acid composition with bioactivity. Prickly pear oil exhibited the highest PUFA content (65.1%), mainly linoleic acid. Calophyllum oil was richer in saturated and monounsaturated fatty acids. All oils showed significant radical scavenging ability, with calophyllum oil showing the lowest DPPH IC<sub>50</sub> and borage oil, the highest ABTS activity. Borage and prickly pear oils demonstrated strong anti-arthritic potential. Calophyllum oil showed the most potent AChE inhibition. All oils showed tyrosinase inhibition; however, calophyllum did not show BChE inhibitory activity. Antibiofilm activity was species- and dose-dependent, with <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Acinetobacter baumannii</i> being most affected. Thus, the tested oils exhibited multiple biological activities, influenced by their fatty acid composition. The in vitro antioxidant, anti-arthritic, neuroprotective, and antimicrobial properties support their potential use as functional food ingredients or nutraceuticals, especially for aging-related health concerns. 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Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.
Seed oils from Borago officinalis (borage), Opuntia ficus-indica (prickly pear), and Calophyllum inophyllum (calophyllum or tamanu) are rich in bioactive fatty acids and have been traditionally used in cosmetic and industrial sectors. This study explored their fatty acid composition and investigated their in vitro antioxidant, anti-arthritic, neuroprotective, and antibiofilm activities. Fatty acid profiles were determined via gas chromatography. Antioxidant activity was assessed using DPPH and ABTS radical scavenging assays. Anti-arthritic potential was measured via bovine serum albumin denaturation. Neuroprotective properties were evaluated through acetylcholinesterase, butirylcholinesterase, and tyrosinase inhibition. Antibiofilm activity against five pathogenic strains was analyzed using crystal violet and MTT assays. Correlation analysis was used to associate fatty acid composition with bioactivity. Prickly pear oil exhibited the highest PUFA content (65.1%), mainly linoleic acid. Calophyllum oil was richer in saturated and monounsaturated fatty acids. All oils showed significant radical scavenging ability, with calophyllum oil showing the lowest DPPH IC50 and borage oil, the highest ABTS activity. Borage and prickly pear oils demonstrated strong anti-arthritic potential. Calophyllum oil showed the most potent AChE inhibition. All oils showed tyrosinase inhibition; however, calophyllum did not show BChE inhibitory activity. Antibiofilm activity was species- and dose-dependent, with Staphylococcus aureus, Escherichia coli, and Acinetobacter baumannii being most affected. Thus, the tested oils exhibited multiple biological activities, influenced by their fatty acid composition. The in vitro antioxidant, anti-arthritic, neuroprotective, and antimicrobial properties support their potential use as functional food ingredients or nutraceuticals, especially for aging-related health concerns. Further in vivo and clinical studies are needed to confirm their efficacy.
AntioxidantsBiochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍:
Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.