琉璃苣、甘蓝和刺梨籽油的脂肪酸谱和一些有用的生物学方面:对健康和饮食使用的影响。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Florinda Fratianni, Francesca Coppola, Siria Tavaniello, Maria Neve Ombra, Beatrice De Giulio, Nunzio D'Agostino, Gokhan Zengin, Raffaele Coppola, Filomena Nazzaro
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引用次数: 0

摘要

琉璃苣(Borago officinalis),仙人掌(Opuntia ficus-indica)和Calophyllum inophyllum (Calophyllum或tamanu)的种子油富含生物活性脂肪酸,传统上用于化妆品和工业部门。本研究探讨了其脂肪酸组成,并对其体外抗氧化、抗关节炎、神经保护和抗生物膜活性进行了研究。脂肪酸谱通过气相色谱法测定。采用DPPH和ABTS自由基清除试验评估抗氧化活性。通过牛血清白蛋白变性测定抗关节炎潜能。通过抑制乙酰胆碱酯酶、丁基胆碱酯酶和酪氨酸酶来评估神经保护作用。用结晶紫法和MTT法分析了对5种病原菌的抗菌活性。利用相关分析将脂肪酸组成与生物活性联系起来。刺梨油中PUFA含量最高(65.1%),主要为亚油酸。花椒油中饱和脂肪酸和单不饱和脂肪酸含量较高。所有油脂均表现出显著的自由基清除能力,其中甘嫩叶油脂的DPPH IC50最低,琉璃苣油脂的ABTS活性最高。琉璃苣和刺梨精油显示出很强的抗关节炎潜力。花椒油对乙酰胆碱酯酶的抑制作用最强。所有油脂均有酪氨酸酶抑制作用;而胼胝体未表现出BChE抑制活性。抗菌膜的活性呈种类和剂量依赖性,其中金黄色葡萄球菌、大肠杆菌和鲍曼不动杆菌受影响最大。因此,被测油脂表现出多种生物活性,受其脂肪酸组成的影响。体外抗氧化、抗关节炎、神经保护和抗菌特性支持其作为功能性食品成分或营养保健品的潜在用途,特别是用于与衰老相关的健康问题。需要进一步的体内和临床研究来证实其有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.

Seed oils from Borago officinalis (borage), Opuntia ficus-indica (prickly pear), and Calophyllum inophyllum (calophyllum or tamanu) are rich in bioactive fatty acids and have been traditionally used in cosmetic and industrial sectors. This study explored their fatty acid composition and investigated their in vitro antioxidant, anti-arthritic, neuroprotective, and antibiofilm activities. Fatty acid profiles were determined via gas chromatography. Antioxidant activity was assessed using DPPH and ABTS radical scavenging assays. Anti-arthritic potential was measured via bovine serum albumin denaturation. Neuroprotective properties were evaluated through acetylcholinesterase, butirylcholinesterase, and tyrosinase inhibition. Antibiofilm activity against five pathogenic strains was analyzed using crystal violet and MTT assays. Correlation analysis was used to associate fatty acid composition with bioactivity. Prickly pear oil exhibited the highest PUFA content (65.1%), mainly linoleic acid. Calophyllum oil was richer in saturated and monounsaturated fatty acids. All oils showed significant radical scavenging ability, with calophyllum oil showing the lowest DPPH IC50 and borage oil, the highest ABTS activity. Borage and prickly pear oils demonstrated strong anti-arthritic potential. Calophyllum oil showed the most potent AChE inhibition. All oils showed tyrosinase inhibition; however, calophyllum did not show BChE inhibitory activity. Antibiofilm activity was species- and dose-dependent, with Staphylococcus aureus, Escherichia coli, and Acinetobacter baumannii being most affected. Thus, the tested oils exhibited multiple biological activities, influenced by their fatty acid composition. The in vitro antioxidant, anti-arthritic, neuroprotective, and antimicrobial properties support their potential use as functional food ingredients or nutraceuticals, especially for aging-related health concerns. Further in vivo and clinical studies are needed to confirm their efficacy.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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