小HDL亚类的减少预示肝硬化患者生存不良。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anja Pammer, Tobias Madl, Hansjörg Habisch, Jakob Kerbl-Knapp, Florian Rainer, Vanessa Stadlbauer, Angela Horvath, Philipp Douschan, Rudolf E Stauber, Gunther Marsche
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引用次数: 0

摘要

肝硬化是一种以氧化应激、炎症和代谢功能障碍为特征的复杂疾病,可导致全身并发症和高死亡率。高密度脂蛋白(HDL),特别是其小亚类,以其抗氧化、抗炎和胆固醇外排能力而闻名。本研究检查了肝硬化中HDL亚类分布和组成的变化,并评估了它们与死亡率的预后相关性。与健康对照组(n = 16)相比,我们使用核磁共振波谱分析代偿性肝硬化(n = 205)和失代偿性肝硬化(n = 158)患者的HDL谱。在肝硬化患者的所有HDL亚类中,胆固醇含量降低,甘油三酯水平升高。特别是,代偿性肝硬化与小和特小HDL颗粒的显著减少有关,而大HDL水平保持不变。这种减少在失代偿疾病中更为明显。小HDL颗粒水平与氧化应激标志物和肝功能障碍呈负相关,即使在调整MELD评分后,也能独立预测代偿性肝硬化患者12个月的死亡率。总之,我们的研究结果强调了小和特小HDL颗粒的大量消耗是肝硬化的一个关键特征,与代偿期的氧化应激和死亡率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis.

Liver cirrhosis is a complex condition characterized by oxidative stress, inflammation, and metabolic dysfunction, contributing to systemic complications and high mortality. High-density lipoprotein (HDL), particularly its small subclasses, is known for its antioxidant, anti-inflammatory, and cholesterol efflux capacities. This study examined changes in HDL subclass distribution and composition in cirrhosis and assessed their prognostic relevance for mortality. We analyzed HDL profiles using nuclear magnetic resonance spectroscopy in patients with compensated (n = 205) and decompensated (n = 158) cirrhosis, compared to healthy controls (n = 16). Across all HDL subclasses in cirrhotic patients, cholesterol content was decreased, and triglyceride levels were elevated. In particular, compensated cirrhosis was associated with a marked reduction in small and extra-small HDL particles, while large HDL levels remained unchanged. This reduction was even more pronounced in decompensated disease. Small HDL particle levels were inversely correlated with oxidative stress markers and liver dysfunction and independently predicted 12-month mortality in patients with compensated cirrhosis, even after adjusting for MELD score. In conclusion, our findings highlight a substantial depletion of small and extra-small HDL particles as a key feature of cirrhosis, linked to oxidative stress and mortality in the compensated stage.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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