肉桂霉对小鼠和大鼠肝功能生物标志物的比较疗效:网络荟萃分析。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Chien-Liang Kuo, Berne Ting, Ray Jui-Hung Tseng, Shih-Ping Liu, Jun-Yang Liou
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引用次数: 0

摘要

本研究采用网络荟萃分析(NMA)方法,系统评估了不同类型和剂量的肉桂提取物(三萜、多糖和泛醌衍生物)对肝功能生物标志物的保护作用,包括丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、丙二醛(MDA)和肿瘤坏死因子-α (TNF-α)。在PubMed、Embase、Cochrane CENTRAL和Web of Science数据库中进行了全面的文献检索,以确定涉及标准化小鼠和大鼠模型的符合条件的动物研究。根据提取物类型和剂量水平(高、中、低)对干预措施进行分类,对照组包括阴性组(载体处理)和阳性组(例如水飞蓟素、n -乙酰半胱氨酸)。随机效应模型以95%置信区间(ci)估计平均差异(MDs),用sycle工具评估偏倚风险,敏感性分析验证了稳健性。协议已经在INPLASY (INPLASY202540040)中注册。结果表明,三萜类化合物,特别是高、中剂量,对降低ALT (MD: -42.37, 95% CI: -54.19 ~ -30.54)和AST (MD: -50.18, 95% CI: -73.31 ~ -27.05)最有效。高剂量多糖也表现出显著的效果,而其他干预措施表现出不同的效果。对于氧化应激,高剂量三萜对MDA的降低最为显著(MD: -19.05, 95% CI: -24.00 ~ -14.09),其次是中剂量三萜和全剂量多糖。对于炎症,高、中剂量三萜显著降低TNF-α水平(高剂量MD: -88.75, 95% CI: -119.68 ~ -57.82;中剂量MD: -89.27, 95% CI: -125.51 ~ -53.02),重叠置信区间表明相似的疗效。高剂量和低剂量多糖也表现出中等的抗炎作用。总之,高剂量三萜在多种生物标志物上显示出良好且一致的效果,这突出了它们在未来肝脏相关治疗策略中的潜在价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Efficacy of Antrodia cinnamomea on Liver Function Biomarkers in Mice and Rats: A Network Meta-Analysis.

This study systematically evaluates the hepatoprotective effects of different types and doses of Antrodia cinnamomea extracts (triterpenoids, polysaccharides, and ubiquinone derivatives) on liver function biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α), using a network meta-analysis (NMA) approach. Comprehensive literature searches were conducted in PubMed, Embase, Cochrane CENTRAL, and Web of Science databases to identify eligible animal studies involving standardized mouse and rat models. Interventions were categorized based on extract types and dosage levels (high, medium, low), with controls including negative groups (vehicle-treated) and positive groups (e.g., silymarin, N-acetylcysteine). A random-effects model estimated mean differences (MDs) with 95% confidence intervals (CIs), risk of bias was assessed with the SYRCLE tool, and sensitivity analyses verified robustness. The protocol has been registered in INPLASY (INPLASY202540040). The results indicated that triterpenoids, particularly at high and medium doses, were the most effective in reducing ALT (MD: -42.37, 95% CI: -54.19 to -30.54) and AST (MD: -50.18, 95% CI: -73.31 to -27.05). High-dose polysaccharides also showed notable effects, while other interventions demonstrated variable efficacy. For oxidative stress, high-dose triterpenoids showed the most pronounced reduction in MDA (MD: -19.05, 95% CI: -24.00 to -14.09), followed by medium-dose triterpenoids and all-dose polysaccharides. Regarding inflammation, high- and medium-dose triterpenoids significantly reduced TNF-α levels (high-dose MD: -88.75, 95% CI: -119.68 to -57.82; medium-dose MD: -89.27, 95% CI: -125.51 to -53.02), with overlapping confidence intervals indicating similar efficacy. High- and low-dose polysaccharides also demonstrated moderate anti-inflammatory effects. In conclusion, high-dose triterpenoids showed favorable and consistent effects across multiple biomarkers, which highlights their potential value for future liver-related therapeutic strategies.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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