脑动静脉畸形位置与临床和血管结构特征的相关性：一种基于体素的病变症状映射方法

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-06-24 DOI:10.1016/j.jneumeth.2025.110519

Haroun Ghannouchi , Jie Wang , Tom Boeken , Emily Rius , Xavier Guerra , Kevin Premat , Julien Allard , Pierre-Marie Chiaroni , Stéphanie Lenck , Mahmoud Elhorany , Atika Talbi , Bertrand Mathon , Aurélien Nouet , Alice Jacquens , Mehdi Drir , Nader-Antoine Sourour , Frédéric Clarençon , Eimad Shotar

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引用次数: 0

摘要

脑动静脉畸形（bAVMs）是一种潜在的侵袭性神经系统疾病。我们的目的是评估基于体素的病变症状映射（VLSM）对脑脊髓瘤的适用性，并将该方法扩展到将脑脊髓瘤的位置与迄今为止未知的疾病方面相关联。这项单中心回顾性研究纳入了1998年至2022年间的所有成年患者，采用可用的预处理MRI扫描3D增强t1加权快速破坏梯度回忆采集，病灶大小>； 5 mm，近期无出血。进行空间归一化和半自动焦点分割。通过单变量分析和VLSM管道进行了位置与癫痫和头痛相关的验证性试验。进行探索性VLSM分析。结果共纳入168例bavm患者164例，平均年龄38岁，29-52岁；85人)。分类定位变量的统计分析证实，癫痫发作显示的脑卒中与颞叶定位呈正相关（p = 0.028），头痛与枕叶定位呈正相关（p = 0.027）。VLSM分析未能复制这些结果作为阳性对照。探索性分析显示近端血流相关动脉瘤（13/155个bAVMs， 8.39 %）与中央脑回位置有显著相关性（z >； 4.03,p <； 0.05）。单因素和多因素分析证实了这一结果。与基于bAVM位置作为分类变量的统计分析相比，VLSM提供了更高的空间分辨率，但代价是灵敏度降低。结论应用VLSM将位置与临床和血管建筑学特征相关联需要庞大的数据集才能获得足够的统计能力。近端血流相关动脉瘤可能与中脑回位置有关。

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Correlating brain arteriovenous malformations location with clinical and angio-architectural characteristics: A voxel-based lesion symptom mapping approach

Background

Brain arteriovenous malformations (bAVMs) are potentially aggressive neurological diseases.

New method

Our aim was to assess the applicability of voxel-based lesion symptom mapping (VLSM) to bAVMs and extend the approach to correlate bAVM location with hitherto unknown aspects of the disease.

This single-center retrospective study of all adult patients managed between 1998 and 2022 with an available pretreatment MRI scan 3D contrast-enhanced T1-weighted fast spoiled gradient-recalled acquisition, a nidus size> 5 mm and no recent hemorrhage. Spatial normalization and semiautomated nidus segmentation were performed. Validatory tests correlating location with epilepsy and headache were conducted with univariate analyses and the VLSM pipeline. Exploratory VLSM analyses were performed.

Results

One hundred and sixty-four patients with 168 bAVMs were included (mean age 38, 29–52[IQR]; 85 men). Statistical analyses on categorical location variables confirmed bAVMs revealed by seizure were positively correlated with temporal lobe location (p = 0.028) while headache was correlated with occipital lobe location (p = 0.027). VLSM analyses failed to reproduce these results as positive controls. Exploratory analyses demonstrated a significant correlation between proximal flow-related aneurysms (13/155 bAVMs, 8.39 %) and central gyri location (z > 4.03, p < 0.05). This result was confirmed by univariate and multivariate analyses.

Comparison with existing methods

In comparison to statistical analyses based on bAVM location as a categorical variable, VLSM offers high spatial resolution at the cost of decreased sensitivity.

Conclusion

Employing VLSM to correlate location and clinical and angioarchitectural characteristics requires large datasets to achieve sufficient statistical power. Proximal flow-related aneurysms might be correlated with bAVM central gyri location.

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.