鸡中抗生素耐药性和产志贺毒素大肠杆菌的全球流行:系统回顾和荟萃分析(2011-2024)。

IF 4.3 2区 医学 Q1 INFECTIOUS DISEASES
Tsepo Ramatla, Nkhebenyane Jane, Mohapi Dineo, Tawana Mpho, Motlhaoloa Tshegofatso, Ntelekwane George Khasapane
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引用次数: 0

摘要

背景:产志贺毒素大肠杆菌(STEC)是重要的食源性病原体,在世界范围内造成严重的公共卫生后果。本研究对全球鸡的抗生素耐药性和产志贺毒素大肠杆菌流行情况进行了系统回顾和荟萃分析。方法:按照系统评价和荟萃分析的首选报告项目(PRISMA)指南对先前的研究记录进行评估。采用基于随机效应模型的Cochrane’s Q检验和I2检验统计量评估研究间的异质性,采用综合meta分析(CMA)软件v4.0分析鸡抗生素耐药性和产肠毒素大肠杆菌的合并患病率估计(PPE)。结果:本研究共纳入61项研究,包括来自18个国家的823例产志贺毒素大肠杆菌。STEC的总总患病率为8.9% (95% CI: 0.620-0.126)。m-PCR检测显示PPE最高,为21.0%(95%:0.088 ~ 0.420)。stx1的PPE为12.9% (95%:0.081 ~ 0.199),stx2的PPE为11.8%(95%:0.077 ~ 0.176)。O157血清型的PPE较高,为80.5%(95%:0.520 ~ 0.940)。对阿莫西林和克拉维酸、氯霉素、四环素、环丙沙星、庆大霉素、氨苄西林、新霉素和阿莫西林耐药。结论:这些发现可能有助于全球鸡产志贺毒素大肠杆菌的预防和控制。为了尽量减少产志毒素大肠杆菌的传播和抗生素耐药性,未来的食源性病原体预防和控制规划应优先考虑提高实验室早期发现抗生素耐药性的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Global Prevalence of Antibiotic Resistance and Shiga Toxin-Producing Escherichia coli in Chickens: A Systematic Review and Meta-Analysis (2011-2024).

Background: Shiga toxin-producing E. coli (STEC) are important foodborne pathogens that cause serious public health consequences worldwide. This study conducted a systematic review and meta-analysis of the global prevalence of antibiotic resistance and STEC in chickens. Methods: The assessment of previous study records was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Heterogeneity between studies was assessed using Cochrane's Q test and I2 test statistics based on the random effects model, and comprehensive meta-analysis (CMA) software v4.0 was used to analyse the pooled prevalence estimate (PPE) of antibiotic resistance and STEC in chickens. Results: A total of 61 studies comprising 823 STEC from 18 countries were included in this study. The overall pooled prevalence of STEC was 8.9% (95% CI: 0.620-0.126). m-PCR assay showed the highest PPE of 21.0% (95%: 0.088-0.420). stx1 had the higher PPE of 12.9% (95%: 0.081-0.199), while stx2 had a PPE of 11.8% (95%: 0.077-0.176). Furthermore, the serotype O157 had the higher PPE of 80.5% (95%: 0.520-0.940). The isolates were resistant to the following antibiotics: amoxicillin and clavulanic acid, chloramphenicol, tetracycline, ciprofloxacin, gentamycin, ampicillin, neomycin, and amoxicillin. Conclusions: These findings may assist in the prevention and control of STEC in chickens globally. To minimise the spread of STEC and antibiotic resistance, future foodborne pathogen prevention and control programmes should prioritise increasing laboratory capacity for the early identification of antibiotic resistance.

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来源期刊
Antibiotics-Basel
Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍: Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
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