接种无毒大肠杆菌活疫苗可提高生产性能,同时显著减少抗菌素的使用。

IF 4.3 2区 医学 Q1 INFECTIOUS DISEASES
Frédéric Vangroenweghe, Thomas Matthijs, Marnix Sinnaeve
{"title":"接种无毒大肠杆菌活疫苗可提高生产性能,同时显著减少抗菌素的使用。","authors":"Frédéric Vangroenweghe, Thomas Matthijs, Marnix Sinnaeve","doi":"10.3390/antibiotics14060547","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>In swine production, the post-weaning period has been identified as one of the most challenging and stressful periods in the life of a piglet due to changes in its environment and feeding regimen. During this period, piglets might undergo infectious challenges with enterotoxigenic <i>Escherichia coli</i> (ETEC) resulting in post-weaning diarrhea (PWD), and meningitis due to <i>Streptococcus suis</i>. Therefore, metaphylactic and curative antimicrobial therapy is frequently applied, which leads to an increased treatment incidence per 100 days at risk (TI<sub>100</sub>).</p><p><strong>Methods: </strong>Here, we report the results of an antimicrobial coaching trajectory in a 1000-sow farm with high antimicrobial use during the post-weaning period. For a period of 21 weeks, we evaluated the effect of an oral live avirulent <i>E. coli</i> F4F18 vaccine (Coliprotec<sup>®</sup> F4F18; Elanco AH) for the active immunization of piglets against PWD caused by F4- and F18-ETEC on the reduction in antimicrobial use during the post-weaning period. A 1000-sow farm with PIC sows operating in a 1-week BMS was rated as an 'attention farm' at the level of the post-weaning period according to the Antimicrobial Consumption and Resistance in Animals (AMCRA) benchmark reporting tool. To analyze the specific approach towards antimicrobial use and the related post-weaning pathology, a farm visit including a biosecurity check was carried out together with all associated stakeholders. Subsequently, an antimicrobial coaching trajectory was utilized to follow-up on the improvement of the reduction in antimicrobial use after implementation of the various pieces of advice.</p><p><strong>Results: </strong>For analytical purposes, we compared the results obtained in period 1 (P1; vaccination week 1-6) to period 2 (P2; vaccination week 7-21), since practical field experience has demonstrated that a 'stabilization period' of about 6 weeks is necessary to obtain the maximal effect of vaccination. There was a significant reduction in mortality (5.7% to 2.0%) and improvement in the average daily weight gain (366 g/d to 392 g/d) following vaccination, with a simultaneous reduction in the number of days in nursery (45 days to 38 days). Meanwhile, the weight at the end of nursery remained at a similar level. There was a clinically relevant though non-significant decrease in the TI<sub>100</sub> (32.8 days to 20.6 days). Overall, the implementation of all measures resulted in a positive ROI of 2.72 per piglet.</p><p><strong>Conclusions: </strong>The implementation of several biosecurity measures in combination with the use of an oral live avirulent <i>E. coli</i> F4F18 vaccine (Coliprotec F4F18) could improve performance parameters and reduce mortality, while reducing the number of days in nursery and the TI<sub>100</sub>. Overall, a positive return on investment of 2.72 could be obtained per piglet produced under these improved conditions.</p>","PeriodicalId":54246,"journal":{"name":"Antibiotics-Basel","volume":"14 6","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189581/pdf/","citationCount":"0","resultStr":"{\"title\":\"Vaccination with a Live Avirulent <i>E. coli</i> Vaccine Resulted in Improved Production Performance Combined with a Significant Reduction in Antimicrobial Use.\",\"authors\":\"Frédéric Vangroenweghe, Thomas Matthijs, Marnix Sinnaeve\",\"doi\":\"10.3390/antibiotics14060547\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>In swine production, the post-weaning period has been identified as one of the most challenging and stressful periods in the life of a piglet due to changes in its environment and feeding regimen. During this period, piglets might undergo infectious challenges with enterotoxigenic <i>Escherichia coli</i> (ETEC) resulting in post-weaning diarrhea (PWD), and meningitis due to <i>Streptococcus suis</i>. Therefore, metaphylactic and curative antimicrobial therapy is frequently applied, which leads to an increased treatment incidence per 100 days at risk (TI<sub>100</sub>).</p><p><strong>Methods: </strong>Here, we report the results of an antimicrobial coaching trajectory in a 1000-sow farm with high antimicrobial use during the post-weaning period. For a period of 21 weeks, we evaluated the effect of an oral live avirulent <i>E. coli</i> F4F18 vaccine (Coliprotec<sup>®</sup> F4F18; Elanco AH) for the active immunization of piglets against PWD caused by F4- and F18-ETEC on the reduction in antimicrobial use during the post-weaning period. A 1000-sow farm with PIC sows operating in a 1-week BMS was rated as an 'attention farm' at the level of the post-weaning period according to the Antimicrobial Consumption and Resistance in Animals (AMCRA) benchmark reporting tool. To analyze the specific approach towards antimicrobial use and the related post-weaning pathology, a farm visit including a biosecurity check was carried out together with all associated stakeholders. Subsequently, an antimicrobial coaching trajectory was utilized to follow-up on the improvement of the reduction in antimicrobial use after implementation of the various pieces of advice.</p><p><strong>Results: </strong>For analytical purposes, we compared the results obtained in period 1 (P1; vaccination week 1-6) to period 2 (P2; vaccination week 7-21), since practical field experience has demonstrated that a 'stabilization period' of about 6 weeks is necessary to obtain the maximal effect of vaccination. There was a significant reduction in mortality (5.7% to 2.0%) and improvement in the average daily weight gain (366 g/d to 392 g/d) following vaccination, with a simultaneous reduction in the number of days in nursery (45 days to 38 days). Meanwhile, the weight at the end of nursery remained at a similar level. There was a clinically relevant though non-significant decrease in the TI<sub>100</sub> (32.8 days to 20.6 days). Overall, the implementation of all measures resulted in a positive ROI of 2.72 per piglet.</p><p><strong>Conclusions: </strong>The implementation of several biosecurity measures in combination with the use of an oral live avirulent <i>E. coli</i> F4F18 vaccine (Coliprotec F4F18) could improve performance parameters and reduce mortality, while reducing the number of days in nursery and the TI<sub>100</sub>. Overall, a positive return on investment of 2.72 could be obtained per piglet produced under these improved conditions.</p>\",\"PeriodicalId\":54246,\"journal\":{\"name\":\"Antibiotics-Basel\",\"volume\":\"14 6\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189581/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antibiotics-Basel\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/antibiotics14060547\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antibiotics-Basel","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/antibiotics14060547","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

背景/目的:在养猪生产中,由于环境和喂养方式的变化,断奶后时期被认为是仔猪一生中最具挑战性和压力的时期之一。在此期间,仔猪可能受到产肠毒素大肠杆菌(ETEC)的感染,导致断奶后腹泻(PWD)和猪链球菌引起的脑膜炎。因此,经常应用变态反应性和治愈性抗菌药物治疗,这导致每100天的治疗风险发生率增加(TI100)。方法:在这里,我们报告了一个在断奶后使用高抗菌药物的1000头母猪农场的抗菌药物指导轨迹的结果。在21周的时间里,我们评估了口服活的无毒大肠杆菌F4F18疫苗(Coliprotec®F4F18;Elanco AH)对仔猪主动免疫F4-和F18-ETEC引起的PWD,减少断奶后抗菌药物的使用。根据动物抗菌素消耗和耐药性(AMCRA)基准报告工具,在断奶后阶段,一个拥有1000头PIC母猪的农场被评为“注意力农场”。为了分析抗菌药物使用的具体方法和相关的断奶后病理,与所有相关利益相关者一起进行了一次农场访问,包括生物安全检查。随后,采用了抗微生物药物指导轨迹来跟踪在实施各种建议后减少抗微生物药物使用的改善情况。结果:为了便于分析,我们比较了第1期(P1;疫苗接种第1-6周)至第2期(P2;疫苗接种周(7-21周),因为实际的现场经验表明,要获得疫苗接种的最大效果,需要大约6周的“稳定期”。接种疫苗后,死亡率显著降低(5.7%至2.0%),平均每日体重增加(366 g/d至392 g/d)得到改善,同时托儿所天数减少(45天至38天)。苗期末体重基本保持不变。TI100有临床相关但不显著的下降(32.8天至20.6天)。总体而言,所有措施的实施使每头仔猪的投资回报率为2.72。结论:在实施多项生物安全措施的同时,使用口服无毒大肠杆菌F4F18活疫苗(Coliprotec F4F18),可改善生产性能参数,降低死亡率,同时减少育婴天数和TI100。总体而言,在这些改良条件下,每头仔猪的投资回报率为2.72。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vaccination with a Live Avirulent E. coli Vaccine Resulted in Improved Production Performance Combined with a Significant Reduction in Antimicrobial Use.

Background/objectives: In swine production, the post-weaning period has been identified as one of the most challenging and stressful periods in the life of a piglet due to changes in its environment and feeding regimen. During this period, piglets might undergo infectious challenges with enterotoxigenic Escherichia coli (ETEC) resulting in post-weaning diarrhea (PWD), and meningitis due to Streptococcus suis. Therefore, metaphylactic and curative antimicrobial therapy is frequently applied, which leads to an increased treatment incidence per 100 days at risk (TI100).

Methods: Here, we report the results of an antimicrobial coaching trajectory in a 1000-sow farm with high antimicrobial use during the post-weaning period. For a period of 21 weeks, we evaluated the effect of an oral live avirulent E. coli F4F18 vaccine (Coliprotec® F4F18; Elanco AH) for the active immunization of piglets against PWD caused by F4- and F18-ETEC on the reduction in antimicrobial use during the post-weaning period. A 1000-sow farm with PIC sows operating in a 1-week BMS was rated as an 'attention farm' at the level of the post-weaning period according to the Antimicrobial Consumption and Resistance in Animals (AMCRA) benchmark reporting tool. To analyze the specific approach towards antimicrobial use and the related post-weaning pathology, a farm visit including a biosecurity check was carried out together with all associated stakeholders. Subsequently, an antimicrobial coaching trajectory was utilized to follow-up on the improvement of the reduction in antimicrobial use after implementation of the various pieces of advice.

Results: For analytical purposes, we compared the results obtained in period 1 (P1; vaccination week 1-6) to period 2 (P2; vaccination week 7-21), since practical field experience has demonstrated that a 'stabilization period' of about 6 weeks is necessary to obtain the maximal effect of vaccination. There was a significant reduction in mortality (5.7% to 2.0%) and improvement in the average daily weight gain (366 g/d to 392 g/d) following vaccination, with a simultaneous reduction in the number of days in nursery (45 days to 38 days). Meanwhile, the weight at the end of nursery remained at a similar level. There was a clinically relevant though non-significant decrease in the TI100 (32.8 days to 20.6 days). Overall, the implementation of all measures resulted in a positive ROI of 2.72 per piglet.

Conclusions: The implementation of several biosecurity measures in combination with the use of an oral live avirulent E. coli F4F18 vaccine (Coliprotec F4F18) could improve performance parameters and reduce mortality, while reducing the number of days in nursery and the TI100. Overall, a positive return on investment of 2.72 could be obtained per piglet produced under these improved conditions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Antibiotics-Basel
Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍: Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信