Jayme C Banks, Sepideh Hariri, Kestutis Kveraga, An Ouyang, Kaileigh Gallagher, Syed A Quadri, Ryan A Tesh, Preeti Upadhyay Reed, Robert J Thomas, M Brandon Westover, Haoqi Sun, Balachundhar Subramaniam
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Using overnight electroencephalography, physiological measures of brain age were derived and subtracted from chronological age, measuring the deviation of apparent brain age from chronological age.</p><p><strong>Results: </strong>Thirty-four participants completed the study (average age = 38 years; 36% female). Estimated brain age index after adjustment by matching: meditators (<i>n</i> = 34), - 5.9 years (<i>SE</i> = 0.94 years, <i>t</i>-test <i>p</i> < 0.001); Dreem healthy controls (<i>n</i> = 1077), - 0.24 (0.61, <i>p</i> < 0.001); Massachusetts General Hospital (MGH) healthy controls (<i>n</i> = 112), 0.55 (0.92, <i>p</i> < 0.05); MGH \"no dementia\" (<i>n</i> = 7618), 2.4 (0.094, reference cohort for <i>t</i>-test); MGH \"symptomatic\" (<i>n</i> = 697), 2.0 (0.33, <i>p</i> > 0.05); MGH \"mild cognitive impairment (MCI)\"(<i>n</i> = 205), 8.8 (2.8, <i>p</i> < 0.05); and MGH \"dementia\" (<i>n</i> = 153), 10.5 (2.8, <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Long-term meditators exhibit lower brain age relative to matched control groups. This study suggests that advanced meditation enhances brain health.</p><p><strong>Preregistration: </strong>This study was not preregistered.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12671-025-02583-y.</p>","PeriodicalId":18523,"journal":{"name":"Mindfulness","volume":"16 6","pages":"1675-1692"},"PeriodicalIF":3.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170783/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sleep-Based Brain Age Is Reduced in Advanced Inner Engineering Meditators.\",\"authors\":\"Jayme C Banks, Sepideh Hariri, Kestutis Kveraga, An Ouyang, Kaileigh Gallagher, Syed A Quadri, Ryan A Tesh, Preeti Upadhyay Reed, Robert J Thomas, M Brandon Westover, Haoqi Sun, Balachundhar Subramaniam\",\"doi\":\"10.1007/s12671-025-02583-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>We aimed to quantify the effects of advanced meditation on brain electrical activity during sleep. This investigation addresses the need for objective neurophysiological measures of meditation's potential impact on brain aging and health.</p><p><strong>Method: </strong>This study was a single-site, prospective cohort study (conducted August 25, 2021, through September 26, 2021) of meditators attending the \\\"Samyama Sadhana\\\" retreat (September 1-5, 2021). Two healthy comparison groups and four comparison groups with varying degrees of age-related brain pathology are included. Using overnight electroencephalography, physiological measures of brain age were derived and subtracted from chronological age, measuring the deviation of apparent brain age from chronological age.</p><p><strong>Results: </strong>Thirty-four participants completed the study (average age = 38 years; 36% female). Estimated brain age index after adjustment by matching: meditators (<i>n</i> = 34), - 5.9 years (<i>SE</i> = 0.94 years, <i>t</i>-test <i>p</i> < 0.001); Dreem healthy controls (<i>n</i> = 1077), - 0.24 (0.61, <i>p</i> < 0.001); Massachusetts General Hospital (MGH) healthy controls (<i>n</i> = 112), 0.55 (0.92, <i>p</i> < 0.05); MGH \\\"no dementia\\\" (<i>n</i> = 7618), 2.4 (0.094, reference cohort for <i>t</i>-test); MGH \\\"symptomatic\\\" (<i>n</i> = 697), 2.0 (0.33, <i>p</i> > 0.05); MGH \\\"mild cognitive impairment (MCI)\\\"(<i>n</i> = 205), 8.8 (2.8, <i>p</i> < 0.05); and MGH \\\"dementia\\\" (<i>n</i> = 153), 10.5 (2.8, <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Long-term meditators exhibit lower brain age relative to matched control groups. 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引用次数: 0
摘要
目的：我们旨在量化高级冥想对睡眠期间脑电活动的影响。这项研究解决了冥想对大脑衰老和健康的潜在影响的客观神经生理学测量的需要。方法：本研究是一项单地点、前瞻性队列研究（于2021年8月25日至2021年9月26日进行），参与者为参加“三山修行”闭关（2021年9月1日至5日）的禅修者。包括两个健康对照组和四个不同程度的年龄相关脑病理对照组。利用夜间脑电图，得出脑年龄的生理指标，并从实足年龄中减去，测量表观脑年龄与实足年龄的偏差。结果：34名参与者完成了研究(平均年龄= 38岁；36%的女性)。经匹配调整后估计脑年龄指数：冥想者（n = 34）、- 5.9岁（SE = 0.94 years， t检验p n = 1077）、- 0.24 （0.61,p n = 112）、0.55 （0.92,p n = 7618）、2.4（0.094，参考队列t检验）；MGH“症状”(n = 697), 2.0 (0.33, p > 0.05);MGH“轻度认知障碍（MCI）”（n = 205）， 8.8 (2.8, p n = 153), 10.5 （2.8, p）。结论：长期冥想者的脑年龄低于对照组。这项研究表明，高级冥想可以促进大脑健康。预注册：本研究未进行预注册。补充资料：在线版本提供补充资料，网址为10.1007/s12671-025-02583-y。
Sleep-Based Brain Age Is Reduced in Advanced Inner Engineering Meditators.
Objectives: We aimed to quantify the effects of advanced meditation on brain electrical activity during sleep. This investigation addresses the need for objective neurophysiological measures of meditation's potential impact on brain aging and health.
Method: This study was a single-site, prospective cohort study (conducted August 25, 2021, through September 26, 2021) of meditators attending the "Samyama Sadhana" retreat (September 1-5, 2021). Two healthy comparison groups and four comparison groups with varying degrees of age-related brain pathology are included. Using overnight electroencephalography, physiological measures of brain age were derived and subtracted from chronological age, measuring the deviation of apparent brain age from chronological age.
Results: Thirty-four participants completed the study (average age = 38 years; 36% female). Estimated brain age index after adjustment by matching: meditators (n = 34), - 5.9 years (SE = 0.94 years, t-test p < 0.001); Dreem healthy controls (n = 1077), - 0.24 (0.61, p < 0.001); Massachusetts General Hospital (MGH) healthy controls (n = 112), 0.55 (0.92, p < 0.05); MGH "no dementia" (n = 7618), 2.4 (0.094, reference cohort for t-test); MGH "symptomatic" (n = 697), 2.0 (0.33, p > 0.05); MGH "mild cognitive impairment (MCI)"(n = 205), 8.8 (2.8, p < 0.05); and MGH "dementia" (n = 153), 10.5 (2.8, p < 0.01).
Conclusions: Long-term meditators exhibit lower brain age relative to matched control groups. This study suggests that advanced meditation enhances brain health.
Preregistration: This study was not preregistered.
Supplementary information: The online version contains supplementary material available at 10.1007/s12671-025-02583-y.
期刊介绍：
Mindfulness seeks to advance research, clinical practice, and theory on mindfulness. It is interested in manuscripts from diverse viewpoints, including psychology, psychiatry, medicine, neurobiology, psychoneuroendocrinology, cognitive, behavioral, cultural, philosophy, spirituality, and wisdom traditions. Mindfulness encourages research submissions on the reliability and validity of assessment of mindfulness; clinical uses of mindfulness in psychological distress, psychiatric disorders, and medical conditions; alleviation of personal and societal suffering; the nature and foundations of mindfulness; mechanisms of action; and the use of mindfulness across cultures. The Journal also seeks to promote the use of mindfulness by publishing scholarly papers on the training of clinicians, institutional staff, teachers, parents, and industry personnel in mindful provision of services. Examples of topics include: Mindfulness-based psycho-educational interventions for children with learning, emotional, and behavioral disorders Treating depression and clinical symptoms in patients with chronic heart failure Yoga and mindfulness Cognitive-behavioral mindfulness group therapy interventions Mindfulnessness and emotional regulation difficulties in children Loving-kindness meditation to increase social connectedness Training for parents and children with ADHD Recovery from substance abuse Changing parents’ mindfulness Child management skills Treating childhood anxiety and depression
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