{"title":"中性粒细胞/高密度脂蛋白胆固醇比值与心血管-肾代谢综合征及其心血管死亡率的关系","authors":"Yaying Xu","doi":"10.3389/fnut.2025.1594041","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome is a novel multi-system disease defined by the American Heart Association (AHA). This study aims to investigate the associations between the neutrophil/high-density lipoprotein cholesterol ratio (NHR) and CKM syndrome and its association with cardiovascular disease (CVD) mortality.</p><p><strong>Methods: </strong>The data for this study were derived from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2018 and the National Death Index (NDI) database. Weighted multivariate logistic regression and Cox regression were the primary analytical methods. restricted cubic spline (RCS) and subgroup analyses were also carried out.</p><p><strong>Results: </strong>A total of 13,165 participants were included in this study. The weighted mean of NHR was 3.14 ± 0.03. The prevalence rate of CKM syndrome was 17.36%. The results of the weighted logistic regression indicated that there was a positive association between NHR and CKM syndrome (OR<sub>per SD</sub>: 1.25, 95% CI: 1.10-1.42, <i>p</i> < 0.001). Among the quartile groups of NHR, the prevalence rate of CKM syndrome showed an increase (<i>p</i> for trend <0.0001). Among individuals with CKM syndrome, the results of the weighted Cox regression demonstrated that NHR also significantly predicted CVD mortality (HR<sub>per SD</sub>: 1.31, 95% CI: 1.14-1.50, <i>p</i> < 0.001). Among the quartile groups of NHR, the risk of CVD mortality also increased in a trend (<i>p</i> for trend = 0.01). Furthermore, RCS analysis showed a positive linear association between NHR and CKM syndrome (non-linear <i>p</i> = 0.075) and between NHR and CVD mortality (non-linear <i>p</i> = 0.300). The subgroup analysis suggested that the relationship between NHR and the outcomes was robust, and there was no significant interaction.</p><p><strong>Conclusion: </strong>Our study demonstrates that NHR is not only associated with an increased prevalence of CKM syndrome but also serves as an effective predictor for CVD mortality in patients with CKM syndrome. This provides new insights into the clinical identification and prognostic evaluation of CKM syndrome.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1594041"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173847/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.\",\"authors\":\"Yaying Xu\",\"doi\":\"10.3389/fnut.2025.1594041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome is a novel multi-system disease defined by the American Heart Association (AHA). This study aims to investigate the associations between the neutrophil/high-density lipoprotein cholesterol ratio (NHR) and CKM syndrome and its association with cardiovascular disease (CVD) mortality.</p><p><strong>Methods: </strong>The data for this study were derived from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2018 and the National Death Index (NDI) database. Weighted multivariate logistic regression and Cox regression were the primary analytical methods. restricted cubic spline (RCS) and subgroup analyses were also carried out.</p><p><strong>Results: </strong>A total of 13,165 participants were included in this study. The weighted mean of NHR was 3.14 ± 0.03. The prevalence rate of CKM syndrome was 17.36%. The results of the weighted logistic regression indicated that there was a positive association between NHR and CKM syndrome (OR<sub>per SD</sub>: 1.25, 95% CI: 1.10-1.42, <i>p</i> < 0.001). Among the quartile groups of NHR, the prevalence rate of CKM syndrome showed an increase (<i>p</i> for trend <0.0001). Among individuals with CKM syndrome, the results of the weighted Cox regression demonstrated that NHR also significantly predicted CVD mortality (HR<sub>per SD</sub>: 1.31, 95% CI: 1.14-1.50, <i>p</i> < 0.001). Among the quartile groups of NHR, the risk of CVD mortality also increased in a trend (<i>p</i> for trend = 0.01). Furthermore, RCS analysis showed a positive linear association between NHR and CKM syndrome (non-linear <i>p</i> = 0.075) and between NHR and CVD mortality (non-linear <i>p</i> = 0.300). The subgroup analysis suggested that the relationship between NHR and the outcomes was robust, and there was no significant interaction.</p><p><strong>Conclusion: </strong>Our study demonstrates that NHR is not only associated with an increased prevalence of CKM syndrome but also serves as an effective predictor for CVD mortality in patients with CKM syndrome. This provides new insights into the clinical identification and prognostic evaluation of CKM syndrome.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"12 \",\"pages\":\"1594041\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173847/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2025.1594041\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1594041","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.
Background: Cardiovascular-kidney-metabolic (CKM) syndrome is a novel multi-system disease defined by the American Heart Association (AHA). This study aims to investigate the associations between the neutrophil/high-density lipoprotein cholesterol ratio (NHR) and CKM syndrome and its association with cardiovascular disease (CVD) mortality.
Methods: The data for this study were derived from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2018 and the National Death Index (NDI) database. Weighted multivariate logistic regression and Cox regression were the primary analytical methods. restricted cubic spline (RCS) and subgroup analyses were also carried out.
Results: A total of 13,165 participants were included in this study. The weighted mean of NHR was 3.14 ± 0.03. The prevalence rate of CKM syndrome was 17.36%. The results of the weighted logistic regression indicated that there was a positive association between NHR and CKM syndrome (ORper SD: 1.25, 95% CI: 1.10-1.42, p < 0.001). Among the quartile groups of NHR, the prevalence rate of CKM syndrome showed an increase (p for trend <0.0001). Among individuals with CKM syndrome, the results of the weighted Cox regression demonstrated that NHR also significantly predicted CVD mortality (HRper SD: 1.31, 95% CI: 1.14-1.50, p < 0.001). Among the quartile groups of NHR, the risk of CVD mortality also increased in a trend (p for trend = 0.01). Furthermore, RCS analysis showed a positive linear association between NHR and CKM syndrome (non-linear p = 0.075) and between NHR and CVD mortality (non-linear p = 0.300). The subgroup analysis suggested that the relationship between NHR and the outcomes was robust, and there was no significant interaction.
Conclusion: Our study demonstrates that NHR is not only associated with an increased prevalence of CKM syndrome but also serves as an effective predictor for CVD mortality in patients with CKM syndrome. This provides new insights into the clinical identification and prognostic evaluation of CKM syndrome.
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No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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