卵巢衰老在单细胞分辨率：当前的范式和观点。

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-06-15 DOI:10.1016/j.arr.2025.102807

Junzhi Liang , Shurui Gai , Xinni Na , Jia Hu , Zhongyu Zhao , Duo Zi , Zhijing Na , Wenyan Gao , Fangfang Bi , Da Li

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引用次数: 0

摘要

卵巢功能衰竭是女性生殖衰老的一个关键因素，导致卵泡储备衰竭和生育能力下降。此外，由于雌激素水平下降，它还会引发全身病理变化，包括骨质疏松症和心血管疾病。尽管有广泛的研究，由于卵巢的多细胞组成和异质性，绘制卵巢衰老细胞是具有挑战性的。在过去的十年中，单细胞分辨率技术通过实现单个细胞的分子表征，为卵巢衰老提供了新的见解。本文就这些技术在延缓卵巢衰老、促进生殖健康方面的应用进行综述。我们总结了它们在揭示细胞类型特异性机制方面的价值及其在卵巢衰老研究中的潜在应用，最终加深我们对其发病机制和分子基础的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ovarian aging at single-cell resolution: Current paradigms and perspectives

Ovarian failure is a key event in female reproductive aging, resulting in the depletion of follicular reserve and a decline in fertility. In addition, it triggers systemic pathological changes, including osteoporosis and cardiovascular disease, due to decreased estrogen levels. Despite extensive study, mapping senescent ovarian cells is challenging due to the multicellular composition and heterogeneity of the ovary. In the past decade, single-cell resolution technologies have provided new insights into ovarian aging by enabling the molecular characterization of individual cells. Here, we comprehensively review the application of these technologies in delaying ovarian aging and promoting reproductive health. We summarize their value in uncovering cell-type-specific mechanisms and their potential uses in the research of ovarian aging, ultimately deepening our understanding of its pathogenesis and molecular basis.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.