川芎多糖对免疫抑制小鼠肠道菌群的影响。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-06-18 DOI:10.1002/jsfa.14433

Dandan Gao, Xingchen Guo, Zhong Yang, Huaxin Li, Ying Chen, Xuankang Yang, Li Song, Xuhua Yang, Jutian Yang, Chenggang Zhou

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引用次数: 0

摘要

背景：肠道微生物生态在维持机体正常生理功能过程中起着重要作用，对免疫系统也有重要影响。然而，关于其对肠道菌群和体内免疫调节作用的研究还不够。结果：本研究采用环磷酰胺给药，建立小鼠免疫抑制模型。本实验研究了白桦多糖（SLMPs）对免疫抑制小鼠免疫及肠道菌群的调节作用。结果表明，SLMPs能减轻小鼠脾脏和胸腺损伤，保护免疫器官，增加小鼠血液中白细胞、淋巴细胞、中性粒细胞和单核细胞的水平，上调小鼠血清中IL-2、IFN-γ、TNF-α和IgA的水平。此外，SLMPs可以恢复免疫抑制小鼠肠道微生物失衡，增强肠道微生物多样性。结论：SLMPs具有增强小鼠免疫力、改善肠道菌群结构和丰度的作用。这些结果为SLMPs在免疫调节佐剂和功能食品中的进一步开发利用提供了理论依据，从而促进其在这些领域的应用。©2025化学工业协会。

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Effects of Sibiraea laevigate maxim polysaccharides on intestinal flora in immunosuppressed mice.

Background: The intestinal microbial ecology plays a significant role in maintaining normal physiological function processes and significantly influences the immune system. However, research regarding its effects on gut flora and in vivo immunomodulation is insufficient.

Results: In this study, cyclophosphamide was administered to mice to establish an immunosuppressed mouse model. The regulatory effects of Sibiraea laevigata maxim polysaccharides (SLMPs) on immunity and intestinal microbiota in the immunosuppressed mouse model were investigated. The results indicated that SLMPs could mitigate spleen and thymus damage, protect immune organs, increase the levels of leukocytes, lymphocytes, neutrophils and monocytes in mouse blood and upregulate the levels of IL-2, IFN-γ, TNF-α and IgA in mouse serum. Furthermore, SLMPs can restore intestinal microbial imbalance and enhance the diversity of gut microorganisms in immunosuppressed mice.

Conclusion: The findings from this study indicated that SLMPs could enhance immunity and improve the structure and abundance of intestinal flora in mice. These results provide a theoretical basis for the further development and utilization of SLMPs in immunomodulatory adjuvants and functional foods, thereby promoting their application in these fields. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.