EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Noël Dierick, Montserrat Anguita, Matteo L. Innocenti, Marianna Kujawa, Jordi Ortuño
{"title":"由黄绿木霉DSM 33578 (Huvezym®neXo)生产的内切-1,4- β -葡聚糖酶、内切-1,4- β -葡聚糖酶和木葡聚糖特异性内切- β -1,4-葡聚糖酶组成的饲料添加剂对所有猪种和所有家禽的功效(Huvepharma EOOD)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Noël Dierick, Montserrat Anguita, Matteo L. Innocenti, Marianna Kujawa, Jordi Ortuño","doi":"10.2903/j.efsa.2025.9460","DOIUrl":null,"url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo-1,4-beta-xylanase, endo-1,4-beta-glucanase and xyloglucan-specific-endo-beta-1,4-glucanase (produced with <i>Trichoderma citrinoviride</i> DSM 33578) (Huvezym® neXo), intended to be used as a zootechnical feed additive (functional group: digestibility enhancers) for all <i>Suidae</i> and all poultry at the recommended application level 1500 endo-pentosanase units (EPU), 100 cellulase unit (CU) and 100 xyloglucanase unit (XGU)/kg of complete feed. The additive is available in granulated (Huvezym® neXo 100 G) and liquid (Huvezym® neXo100 L) forms, and it is authorised for use in reproductive sows and poultry for fattening, poultry reared for laying and reared for breeding, and ornamental birds. In previous opinions, the FEEDAP Panel concluded that Huvezym® neXo is safe for the target species, consumers and the environment. Additionally, the FEEDAP Panel concluded that Huvezym® neXo in either form is not an irritant to the skin and eyes; the liquid form is not a skin sensitiser, but the solid form should be considered a potential skin sensitiser. Both forms of the additive are considered respiratory sensitisers. However, in the previous assessments, the Panel could not conclude on the efficacy of weaned piglets and laying hens. Considering the previously and newly submitted data the Panel concluded that the additive has a potential to be efficacious as a zootechnical additive for all porcine species and all poultry under the proposed conditions of use.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 6","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9460","citationCount":"0","resultStr":"{\"title\":\"Efficacy of a feed additive consisting of endo-1,4-beta-xylanase, endo-1,4-beta-glucanase and xyloglucan-specific-endo-beta-1,4-glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo) for all porcine species and all poultry (Huvepharma EOOD)\",\"authors\":\"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Ilen Röhe, Katerina Theodoridou, Noël Dierick, Montserrat Anguita, Matteo L. Innocenti, Marianna Kujawa, Jordi Ortuño\",\"doi\":\"10.2903/j.efsa.2025.9460\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo-1,4-beta-xylanase, endo-1,4-beta-glucanase and xyloglucan-specific-endo-beta-1,4-glucanase (produced with <i>Trichoderma citrinoviride</i> DSM 33578) (Huvezym® neXo), intended to be used as a zootechnical feed additive (functional group: digestibility enhancers) for all <i>Suidae</i> and all poultry at the recommended application level 1500 endo-pentosanase units (EPU), 100 cellulase unit (CU) and 100 xyloglucanase unit (XGU)/kg of complete feed. The additive is available in granulated (Huvezym® neXo 100 G) and liquid (Huvezym® neXo100 L) forms, and it is authorised for use in reproductive sows and poultry for fattening, poultry reared for laying and reared for breeding, and ornamental birds. In previous opinions, the FEEDAP Panel concluded that Huvezym® neXo is safe for the target species, consumers and the environment. Additionally, the FEEDAP Panel concluded that Huvezym® neXo in either form is not an irritant to the skin and eyes; the liquid form is not a skin sensitiser, but the solid form should be considered a potential skin sensitiser. Both forms of the additive are considered respiratory sensitisers. However, in the previous assessments, the Panel could not conclude on the efficacy of weaned piglets and laying hens. Considering the previously and newly submitted data the Panel concluded that the additive has a potential to be efficacious as a zootechnical additive for all porcine species and all poultry under the proposed conditions of use.</p>\",\"PeriodicalId\":11657,\"journal\":{\"name\":\"EFSA Journal\",\"volume\":\"23 6\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9460\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EFSA Journal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025.9460\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EFSA Journal","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025.9460","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Efficacy of a feed additive consisting of endo-1,4-beta-xylanase, endo-1,4-beta-glucanase and xyloglucan-specific-endo-beta-1,4-glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo) for all porcine species and all poultry (Huvepharma EOOD)
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo-1,4-beta-xylanase, endo-1,4-beta-glucanase and xyloglucan-specific-endo-beta-1,4-glucanase (produced with Trichoderma citrinoviride DSM 33578) (Huvezym® neXo), intended to be used as a zootechnical feed additive (functional group: digestibility enhancers) for all Suidae and all poultry at the recommended application level 1500 endo-pentosanase units (EPU), 100 cellulase unit (CU) and 100 xyloglucanase unit (XGU)/kg of complete feed. The additive is available in granulated (Huvezym® neXo 100 G) and liquid (Huvezym® neXo100 L) forms, and it is authorised for use in reproductive sows and poultry for fattening, poultry reared for laying and reared for breeding, and ornamental birds. In previous opinions, the FEEDAP Panel concluded that Huvezym® neXo is safe for the target species, consumers and the environment. Additionally, the FEEDAP Panel concluded that Huvezym® neXo in either form is not an irritant to the skin and eyes; the liquid form is not a skin sensitiser, but the solid form should be considered a potential skin sensitiser. Both forms of the additive are considered respiratory sensitisers. However, in the previous assessments, the Panel could not conclude on the efficacy of weaned piglets and laying hens. Considering the previously and newly submitted data the Panel concluded that the additive has a potential to be efficacious as a zootechnical additive for all porcine species and all poultry under the proposed conditions of use.
期刊介绍:
The EFSA Journal covers methods of risk assessment, reports on data collected, and risk assessments in the individual areas of plant health, plant protection products and their residues, genetically modified organisms, additives and products or substances used in animal feed, animal health and welfare, biological hazards including BSE/TSE, contaminants in the food chain, food contact materials, enzymes, flavourings and processing aids, food additives and nutrient sources added to food, dietetic products, nutrition and allergies.