幼儿源记忆编码相关神经信号的多模态分析

IF 4.9 2区 医学 Q1 NEUROSCIENCES
Yuqing Lei , John Richards , Fengji Geng , Tracy Riggins
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引用次数: 0

摘要

源记忆的出现是记忆发展的一个重要里程碑。几十年的研究利用脑电图(EEG)和功能磁共振成像(fMRI)探索了源记忆的神经相关性。然而,两种方法的发现之间的联系,特别是在儿童中,仍然不清楚。本研究确定了在记忆编码过程中两个脑电信号的fmri皮质源,P2和晚慢波(LSW),预测了4至8岁儿童的后续源记忆表现。P2和LSW均来源于内侧颞叶皮质区,反映了内侧颞叶在早期信息加工和后期记忆整合中的重要作用,验证了内侧颞叶在记忆更新中的作用。P2效应定位于左、右半球皮层MTL的所有6个测试亚区,而LSW效应仅定位于海马旁皮层和内嗅皮层。此外,P2位于额顶叶网络的多个区域,表明记忆编码与其他认知功能之间存在相互作用。这些结果反映了考虑神经活动的空间和时间方面来解码记忆机制的重要性和潜力,为未来的发展研究铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multimodal analysis of neural signals related to source memory encoding in young children
The emergence of source memory is an important milestone during memory development. Decades of research has explored neural correlates of source memory using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). However, connections between findings from the two approaches, particularly within children, remain unclear. This study identified fMRI-informed cortical sources of two EEG signals during memory encoding, the P2 and the late slow wave (LSW), that predicted subsequent source memory performance in a sample of children aged 4 to 8 years. Both P2 and LSW were source localized to cortical areas of the medial temporal lobe (MTL), reflecting MTL’s crucial role in both early-stage information processing and late-stage integration of memory, and validating LSW’s suspected role in memory updating. The P2 effect was localized to all six tested subregions of cortical MTL in both left and right hemispheres, whereas the LSW effect was only localized to the parahippocampal cortex and entorhinal cortex. P2 was additionally localized to multiple areas in the frontoparietal network, suggesting interactions between memory encoding and other cognitive functions. These results reflect the importance and potential of considering both spatial and temporal aspects of neural activity to decode memory mechanisms, paving the way for future developmental research.
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来源期刊
CiteScore
7.60
自引率
10.60%
发文量
124
审稿时长
6-12 weeks
期刊介绍: The journal publishes theoretical and research papers on cognitive brain development, from infancy through childhood and adolescence and into adulthood. It covers neurocognitive development and neurocognitive processing in both typical and atypical development, including social and affective aspects. Appropriate methodologies for the journal include, but are not limited to, functional neuroimaging (fMRI and MEG), electrophysiology (EEG and ERP), NIRS and transcranial magnetic stimulation, as well as other basic neuroscience approaches using cellular and animal models that directly address cognitive brain development, patient studies, case studies, post-mortem studies and pharmacological studies.
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