探索影响成人饮食行为的基因修饰：范围综述。

IF 3.8 2区医学 Q1 BEHAVIORAL SCIENCES

Appetite Pub Date : 2025-06-16 DOI:10.1016/j.appet.2025.108193

Julie E. Brown, Lillian Morton, Andrea J. Braakhuis

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引用次数: 0

摘要

破坏性饮食行为会对心理健康产生负面影响，并增加肥胖、2型糖尿病和心血管疾病等代谢性疾病的风险。虽然行为策略仍然是饮食干预的核心，但新兴研究强调遗传因素，特别是单核苷酸多态性（snp），是导致饮食行为个体差异的因素。这范围审查地图现有的研究对成人饮食行为的遗传修饰，确定关键变异和遗传倾向。在12个电子数据库中进行了广泛的系统搜索，包括PubMed， MEDLINE和EMBASE，以及相关的灰色文献。2014年至2024年4月发表的65项研究符合纳入标准。利用Covidence和NVivo对数据进行综合，进行专题制图。如果研究使用有效的问卷调查和/或饮食干预，利用基因分型检查与成人饮食行为相关的遗传标记、变异或snp，则该研究是合格的。出现了六个关键主题：味觉；食欲和饱腹感；情绪化进食;抑制解除;进食时间和饮食习惯；吃零食，渴望和暴饮暴食。常被研究的基因包括CD36、MC4R、FTO、TAS1R、TAS2R、SLC4A5、SLC6A2、SLC6A4、DRD2、CLOCK、ADIPOQ和CA6，一些研究还纳入了遗传风险评分。在回顾的研究中，女性占主导地位（男女比例为1.6:1），而老年人代表性不足（平均年龄：35.2±8.4岁）。横断面研究设计（58%），强调了方法学上的差距，强调了纵向研究探索因果关系的必要性。这篇综述为饮食行为的遗传基础提供了有价值的见解，并强调未来需要在更多样化的人群中进行研究，以支持精确的营养策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring genetic modifiers influencing adult eating behaviour: A scoping review

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Exploring genetic modifiers influencing adult eating behaviour: A scoping review

Disruptive eating behaviors can negatively impact psychological well-being and increase the risk of metabolic diseases such as obesity, type 2 diabetes, and cardiovascular disease. While behavioral strategies remain central to dietary interventions, emerging research highlights genetic factors, particularly single nucleotide polymorphisms (SNPs), as contributors to individual differences in eating behaviors. This scoping review maps existing research on genetic modifiers of adult eating behaviors, identifying key variants and genetic predispositions.

An extensive systematic search was conducted across 12 electronic databases, including PubMed, MEDLINE, and EMBASE, alongside relevant grey literature. Sixty-five studies published from 2014 to April 2024 met inclusion criteria. Data were synthesized using Covidence and NVivo for thematic mapping. Studies were eligible if they utilized genotyping to examine genetic markers, variations, or SNPs in relation to adult eating behaviors using validated questionnaires and/or dietary interventions. Six key themes emerged: taste perception; appetite and satiety; emotional eating; disinhibition; food timing and eating habits; and snacking, craving and binge eating. Frequently studied genes included CD36, MC4R, FTO, TAS1R, TAS2R, SLC4A5, SLC6A2, SLC6A4, DRD2, CLOCK, ADIPOQ and CA6, with some studies incorporating genetic risk scores. Across reviewed studies, there was a female predominance (female-to-male ratio of 1.6:1), while older adults were underrepresented (mean age: 35.2 ± 8.4 years). Cross-sectional study designs (58 %), highlighted a methodological gap, underscoring the need for longitudinal research to explore causality.

This review provides valuable insights into the genetic underpinnings of eating behaviors and emphasizes the need for future research in more diverse populations to support precision nutrition strategies.

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来源期刊

Appetite 医学-行为科学

CiteScore

9.10

自引率

11.10%

发文量

566

审稿时长

13.4 weeks

期刊介绍： Appetite is an international research journal specializing in cultural, social, psychological, sensory and physiological influences on the selection and intake of foods and drinks. It covers normal and disordered eating and drinking and welcomes studies of both human and non-human animal behaviour toward food. Appetite publishes research reports, reviews and commentaries. Thematic special issues appear regularly. From time to time the journal carries abstracts from professional meetings. Submissions to Appetite are expected to be based primarily on observations directly related to the selection and intake of foods and drinks; papers that are primarily focused on topics such as nutrition or obesity will not be considered unless they specifically make a novel scientific contribution to the understanding of appetite in line with the journal's aims and scope.