口服益生菌补充剂对肥胖患者肠道通透性的作用:一项随机对照试验的系统综述

IF 5.1 Q1 CHEMISTRY, APPLIED
Alpha Fardah Athiyyah , Triska Susila Nindya , Reza Gunadi Ranuh , Andy Darma , Khadijah Rizky Sumitro , Purwo Sri Rejeki , Lilik Djuari , Subijanto Marto Sudarmo , Rina Agustina
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引用次数: 0

摘要

背景:肥胖是一种慢性疾病,是一种全球性的流行病,与生态失调引起的肠道通透性受损有关。据报道,肠道微生物群在肥胖治疗中发挥着潜在的作用。益生菌已成为治疗生态失调最广泛使用的方法。本研究探讨了口服益生菌补充剂对肥胖个体肠道通透性的影响。方法按照系统评价和meta分析的首选报告项目进行系统评价。检索了PubMed、ScienceDirect、PLOS One和Cochrane数据库,以确定2014年至2024年9月之间发表的文章。采用Cochrane随机试验风险偏倚工具评估发表偏倚。结果共纳入690项人类随机对照试验(rct),其中9项符合本综述。益生菌(阿克曼菌、双歧杆菌、肠球菌、乳酸杆菌、链球菌和酵母菌的组合)使用超过8周可能会降低肠道通透性结果,包括血浆带蛋白、粪便带蛋白、血浆或血清LPS、尿乳果糖和尿甘露醇;然而,BMI(身体质量指数)水平在所有组中显示出不一致的测量结果。结论补充益生菌至少8周可降低肠道通透性。然而,需要进一步的研究来制定益生菌菌株、剂量、持续时间和给药方法的标准化方案,以更好地了解它们对肥胖个体肠道通透性和相关结局的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials

Background

Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study explored the effect of oral probiotic supplementation on intestinal permeability in individuals with obesity.

Methods

A Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, ScienceDirect, PLOS One, and Cochrane databases were searched to identify articles published between 2014 and September 2024. The Cochrane risk-of-bias tool for randomized trials was used to assess publication bias.

Results

A total of 690 human RCTs (randomized controlled trials) were identified, of which nine were eligible for this review. Probiotics (Akkermansia, Bifidobacterium, Enterococcus, Lactobacillus, Streptococcus, and a combination of Saccharomyces yeast) used for over 8 weeks may decrease gut permeability outcomes, including plasma zonulin, fecal zonulin, plasma or serum LPS, urinary lactulose, and urinary mannitol; however, BMI (body mass index) levels exhibited inconsistent measurements across all groups.

Conclusions

Probiotic supplementation for a minimum of 8 weeks may reduce gut permeability. However, further studies are required to develop standardized protocols for probiotic strains, dosages, durations, and delivery methods, to better understand their effects on intestinal permeability and related outcomes in individuals with obesity.
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来源期刊
CiteScore
4.50
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