反思黄疸

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-06-12

Joachim Kloehn, Dominique Soldati-Favre

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引用次数: 0

摘要

疟疾仍然是世界上主要的破坏性传染病之一(1)。它是由疟原虫属的一种原生动物寄生虫引起的，由按蚊属的蚊子传播。不幸的是，过去几十年来，对药物和杀虫剂的耐药性以及气候变化正在威胁着疟疾预防、控制和治疗方面的进展。某些人类遗传特征具有一定的抗疟疾能力，并在疟疾流行地区普遍存在。在这期杂志的第1181页，Figueiredo等人(2)报道了一种可能预防这种疾病的遗传性状——胆红素偶联酶的表达降低。结果，非共轭胆红素浓度增加，这具有抗疟疾作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rethinking jaundice

Malaria continues to be among the major devastating infectious diseases in the world (1). It is caused by a protozoan parasite of the genus Plasmodium that is transmitted by mosquitoes in the Anopheles genus. Unfortunately, resistance to drugs and insecticides, as well as climate change, are threatening progress in malaria prevention, control, and treatment over the past decades. Certain human genetic traits confer some protection against malaria and are prevalent in malaria-endemic regions. On page 1181 of this issue, Figueiredo et al. (2) report a genetic trait that may provide protection from the disease—the decreased expression of a bilirubin conjugation enzyme. As a result, unconjugated bilirubin concentrations increase, which has antimalarial effects.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.