外膜蛋白TolC在弧菌中的功能及调控

IF 3.8 2区医学 Q2 CHEMISTRY, MEDICINAL

ACS Infectious Diseases Pub Date : 2025-06-11 DOI:10.1021/acsinfecdis.4c01058

Yue Gong, Chunxia Liu, Xin Tian* and Young Ran Kim*,

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引用次数: 0

摘要

TolC是一种多功能的外膜蛋白，它创造了一个连续的管道，将底物从细菌的外周质和内膜的外叶挤压到外部环境。弧菌的TolC作为多种出口蛋白的外膜蛋白，参与抗生素外排、毒力因子的调控和出口、铁稳态以及各种极端环境下的生存，在弧菌的发病过程中起着不可或缺的作用。本文综述了目前有关弧菌中TolC同源蛋白的功能和调控因子的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Functions and Regulation of the Outer Membrane Protein TolC in Vibrio Species

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Functions and Regulation of the Outer Membrane Protein TolC in Vibrio Species

TolC, a multifunctional outer membrane protein, creates a continuous conduit that extrudes substrates from the bacterial periplasm and the outer leaflet of the inner membrane to the external environment. TolC of Vibrio species functions as an outer membrane protein of multiple exporters, and is involved in antibiotic efflux, regulation and export of virulence factors, iron homeostasis, and survival under various extreme environments, thereby playing an indispensable role in the pathogenesis of Vibrio species. This review recapitulates the current knowledge about the functions and regulators of TolC homologous proteins in Vibrio species.

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来源期刊

ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES

CiteScore

9.70

自引率

3.80%

发文量

213

期刊介绍： ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.