山药淀粉和非淀粉多糖通过改善肠道炎症和调节肠道微生物群来减轻抗生素相关性腹泻。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-06-09 DOI:10.1002/jsfa.14337

Qing Zhang, Qing Wang, Fei Zhang, Suiqing Chen

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引用次数: 0

摘要

背景：山药是一种典型的食物，也可以作为治疗腹泻的传统药物。山药非淀粉多糖（SYP）和淀粉（SYS）是山药中含量最多的成分。本研究旨在研究SYP和SYS对抗生素相关性腹泻（AAD）大鼠的止泻作用及其可能机制。结果：采用混合抗生素溶液口服，每天1次，连续10天制备抗生素相关性腹泻大鼠模型。然后，大鼠口服SYS和SYP，每天1次，连续7天治疗抗生素相关性腹泻。通过粪便含水量、结肠组织病理学、炎症因子和肠道微生物来评估止泻效果并阐明其潜在机制。SYP和SYS降低了AAD大鼠的粪便含水量，改善了结肠黏膜的完整性，减轻了结肠炎症反应。此外，SYP和SYS显著增加了AAD大鼠肠道菌群的丰度和多样性。模型组（抗生素对照组）肠球菌、Lachnoclostridium、Bacteroides、clostridiides、Clostridiales_unclassified、Serratia和Lachnospiraceae_NK4A136_group的相对丰度发生了显著变化。肠球菌（Enterococcus）、拟杆菌（Bacteroides）、梭状芽孢杆菌（clostridiides）、未分类梭状芽孢杆菌（Clostridiales_unclassified）、沙雷氏菌（Serratia）和Lachnospiraceae_NK4A136_group)的丰度在SYS治疗后恢复。肠球菌、梭状芽孢杆菌和沙雷菌的丰度在SYP治疗后被召回。结论：SYS和SYP可通过改善结肠炎症反应和重建肠道菌群来改善抗生素相关性腹泻。©2025化学工业协会。

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Chinese yam starch and non-starch polysaccharides alleviated antibiotic-associated diarrhea by ameliorating intestinal inflammation and regulating intestinal microbiotas.

Background: Yam is a typical food and can also be used as traditional medicine in treating diarrhea. Yam non-starch polysaccharides (SYP) and starch (SYS) are the most abundant ingredients in yam. The present study aimed to study the antidiarrheal effects and potential mechanisms of SYP and SYS on antibiotic-associated diarrhea (AAD) rats.

Results: A rat model of antibiotic-associated diarrhea was prepared by orally administering a mixed antibiotic solution once a day for 10 consecutive days. Then, the rats were orally administered with SYS and SYP once a day for 7 consecutive days to treat antibiotic associated diarrhea. Fecal water content, colonic histopathology, inflammatory cytokines and intestinal microbiotas were used to evaluate the antidiarrheal effect and elucidate the potential mechanism. SYP and SYS reduced the fecal water content, improved the integrity of the colonic mucosa and alleviated the colonic inflammatory response of AAD rats. Moreover, SYP and SYS significantly increased the abundance and diversity of intestinal microbiotas in AAD rats. The relative abundance of Enterococcus, Lachnoclostridium, Bacteroides, Clostridioides, Clostridiales_unclassified, Serratia and Lachnospiraceae_NK4A136_group had significantly changed in the model (antibiotic control) group. The abundance of Enterococcus, Bacteroides, Clostridioides, Clostridiales_unclassified, Serratia and Lachnospiraceae_NK4A136_group was restored after treatment with SYS. The abundance of Enterococcus, Clostridioides and Serratia was recalled after SYP treatment.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

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