{"title":"催产素可以改善早期生活过度屏幕时间暴露的大鼠模型中的社交缺陷和大脑发育障碍","authors":"Mozhan Parsa , Monireh Mansouri , Hamidreza Pouretemad","doi":"10.1016/j.brainresbull.2025.111419","DOIUrl":null,"url":null,"abstract":"<div><div>In recent years studies have shown that early life excessive screen time exposure may significantly contribute to the emergence of social deficits and autistic-like behaviors. However, the exact underlying mechanisms and the optimal treatment strategies are not completely understood, with conflicting results of preceding findings. This study investigates the effect of oxytocin on autism-related behaviors, and associated brain structure abnormalities induced by excessive audiovisual stimulation (EAVS) as an early life excessive screen exposure model in rats. Neonatal rat pups were exposed to EAVS from postnatal day (PND) 12 to PND 35, and intranasal oxytocin (OXT) at a dose of 0.8 IU/kg was administrated from PND21 to PND35. Behavioral assessment including social interaction, repetitive behavior, locomotor activity, and anxiety-like behavior, along with three-dimensional brain structure measurements were done during adolescence (PND50-PND55). The results revealed EAVS-induced anomalies in social interaction, hyperactivity, and changes in the volume, and neuron number of brain regions including the amygdala and anterior cingulate cortex (ACC) in the EAVS group which were modulated by oxytocin. Our findings suggest that OXT may mitigate adverse effects of early life excessive exposure to digital screens, enhancing social preferences through modulating brain plasticity. The observed neuroanatomical and behavioral alterations highlight the vulnerability of the developing brain to early life excessive screen exposure and suggest a potential therapeutic path through OXT to tackle social impairments induced by EAVS.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"228 ","pages":"Article 111419"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxytocin can ameliorate social deficits and brain developmental impairments in a rat model of early life excessive screen time exposure\",\"authors\":\"Mozhan Parsa , Monireh Mansouri , Hamidreza Pouretemad\",\"doi\":\"10.1016/j.brainresbull.2025.111419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In recent years studies have shown that early life excessive screen time exposure may significantly contribute to the emergence of social deficits and autistic-like behaviors. However, the exact underlying mechanisms and the optimal treatment strategies are not completely understood, with conflicting results of preceding findings. This study investigates the effect of oxytocin on autism-related behaviors, and associated brain structure abnormalities induced by excessive audiovisual stimulation (EAVS) as an early life excessive screen exposure model in rats. Neonatal rat pups were exposed to EAVS from postnatal day (PND) 12 to PND 35, and intranasal oxytocin (OXT) at a dose of 0.8 IU/kg was administrated from PND21 to PND35. Behavioral assessment including social interaction, repetitive behavior, locomotor activity, and anxiety-like behavior, along with three-dimensional brain structure measurements were done during adolescence (PND50-PND55). The results revealed EAVS-induced anomalies in social interaction, hyperactivity, and changes in the volume, and neuron number of brain regions including the amygdala and anterior cingulate cortex (ACC) in the EAVS group which were modulated by oxytocin. Our findings suggest that OXT may mitigate adverse effects of early life excessive exposure to digital screens, enhancing social preferences through modulating brain plasticity. The observed neuroanatomical and behavioral alterations highlight the vulnerability of the developing brain to early life excessive screen exposure and suggest a potential therapeutic path through OXT to tackle social impairments induced by EAVS.</div></div>\",\"PeriodicalId\":9302,\"journal\":{\"name\":\"Brain Research Bulletin\",\"volume\":\"228 \",\"pages\":\"Article 111419\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Research Bulletin\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S036192302500231X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S036192302500231X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Oxytocin can ameliorate social deficits and brain developmental impairments in a rat model of early life excessive screen time exposure
In recent years studies have shown that early life excessive screen time exposure may significantly contribute to the emergence of social deficits and autistic-like behaviors. However, the exact underlying mechanisms and the optimal treatment strategies are not completely understood, with conflicting results of preceding findings. This study investigates the effect of oxytocin on autism-related behaviors, and associated brain structure abnormalities induced by excessive audiovisual stimulation (EAVS) as an early life excessive screen exposure model in rats. Neonatal rat pups were exposed to EAVS from postnatal day (PND) 12 to PND 35, and intranasal oxytocin (OXT) at a dose of 0.8 IU/kg was administrated from PND21 to PND35. Behavioral assessment including social interaction, repetitive behavior, locomotor activity, and anxiety-like behavior, along with three-dimensional brain structure measurements were done during adolescence (PND50-PND55). The results revealed EAVS-induced anomalies in social interaction, hyperactivity, and changes in the volume, and neuron number of brain regions including the amygdala and anterior cingulate cortex (ACC) in the EAVS group which were modulated by oxytocin. Our findings suggest that OXT may mitigate adverse effects of early life excessive exposure to digital screens, enhancing social preferences through modulating brain plasticity. The observed neuroanatomical and behavioral alterations highlight the vulnerability of the developing brain to early life excessive screen exposure and suggest a potential therapeutic path through OXT to tackle social impairments induced by EAVS.
期刊介绍:
The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.