晚期非小细胞肺癌患者支持性护理数字化应用的试点可行性试验。

IF 2.1 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of palliative medicine Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI:10.1089/jpm.2025.0066
Mary C Boulanger, Stephen B Lo, Joely A Centracchio, Brianna Jewett, Madison Freese, Mia Holtze, Jamie M Jacobs, Laura A Petrillo, Jessica Bauman, Areej El-Jawahri, Jennifer S Temel, Joseph A Greer
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引用次数: 0

摘要

背景:晚期非小细胞肺癌(NSCLC)患者会经历沉重的症状、心理困扰和较差的生活质量(QOL)。目的:我们开发并试点测试了一个数字健康应用程序(“THRIVE”),由六个模块组成,旨在改善患者的症状管理和应对非小细胞肺癌。设计:随机试点可行性试验。环境/受试者:符合条件的患者包括在美国某参与机构接受晚期NSCLC诊断治疗的12周内的成年人。测量:参与者完成基线和12周的QOL评估(癌症治疗-肺功能评估),身体症状(MD安德森症状量表;MDASI)、心理困扰(医院焦虑抑郁量表)和应对(Brief COPE)。主要终点是研究可行性,定义为≥65%的接近患者同意参与;≥70%的干预参与者完成6个app模块中的≥4个;≥70%的样本完成了12周的评估。我们使用系统可用性量表(SUS)来评估干预的可接受性。结果:在232例患者中,135例(58.2%)提供了同意,120例(51.7%)被随机分配(平均年龄67.90岁,61.7%为女性,90.8%为白人)。在干预参与者中,70.5%(43/61)完成了≥4个模块,77.3%的人报告THRIVE的SUS可用性评分高于平均水平。94名(78.3%)参与者完成了为期12周的评估。结论:虽然入组率低于预期,但接受THRIVE的晚期NSCLC患者符合app完成的可行性标准,并报告了较高的可接受性。这些结果支持开展THRIVE的后续疗效试验,以改善患者的生活质量、身体症状和其他社会心理结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pilot Feasibility Trial of a Supportive Care Digital Application for Patients with Advanced Nonsmall Cell Lung Cancer.

Background: Patients with advanced nonsmall cell lung cancer (NSCLC) experience burdensome symptoms, psychological distress, and poor quality of life (QOL). Objective: We developed and pilot-tested a digital health application ("THRIVE"), consisting of six modules designed to improve patients' symptom management and coping with NSCLC. Design: Randomized pilot feasibility trial. Setting/Subjects: Eligible patients included adults within 12 weeks of an advanced NSCLC diagnosis receiving care at a participating institution in the United States. Measurements: Participants completed baseline and 12-week assessments of QOL (Functional Assessment of Cancer Therapy-Lung), physical symptoms (MD Anderson Symptom Inventory; MDASI), psychological distress (Hospital Anxiety and Depression Scale), and coping (Brief COPE). The primary outcome was study feasibility, defined as ≥65% of approached patients consenting to participate; ≥70% of intervention participants completing ≥4 of 6 app modules; and ≥70% of the sample completing the 12-week assessments. We used the System Usability Scale (SUS) to assess intervention acceptability. Results: Of 232 patients approached, 135 (58.2%) provided consent, and 120 (51.7%) were randomized (Agemean = 67.90 years, 61.7% female, 90.8% White). Among intervention participants, 70.5% (43/61) completed ≥4 modules, with 77.3% reporting above-average SUS usability ratings for THRIVE. Ninety-four (78.3%) participants completed the 12-week assessments. Conclusions: Although the enrollment rate was lower than anticipated, patients with advanced NSCLC who received THRIVE met the feasibility criterion for app completion and reported high acceptability. These results support conducting a follow-up efficacy trial of THRIVE for improving patients' QOL, physical symptoms, and other psychosocial outcomes.

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来源期刊
Journal of palliative medicine
Journal of palliative medicine 医学-卫生保健
CiteScore
3.90
自引率
10.70%
发文量
345
审稿时长
2 months
期刊介绍: Journal of Palliative Medicine is the premier peer-reviewed journal covering medical, psychosocial, policy, and legal issues in end-of-life care and relief of suffering for patients with intractable pain. The Journal presents essential information for professionals in hospice/palliative medicine, focusing on improving quality of life for patients and their families, and the latest developments in drug and non-drug treatments. The companion biweekly eNewsletter, Briefings in Palliative Medicine, delivers the latest breaking news and information to keep clinicians and health care providers continuously updated.
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