Lusi A, Mina Fakhary, Jennifer M Solano, Mohamed Koroma
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Determination of Folic Acid in Various Dietary Supplement Dosage Forms by UPLC/PDA: Single-Laboratory Validation, First Action 2024.09.
Background: The AOAC Expert Review Panel (ERP) approved a method for the quantification of folic acid in various dietary supplement dosage forms containing tablets, 2-piece capsules, powder drinks, softgels, and gummies as First Action Official Method SM status.
Objective: The previously published method summarized a single-laboratory validation with parameters of linearity, limit of detection, limit of quantification, repeatability, recovery, specificity, and system suitability. Based on the request from ERP, the recovery test for the gummies has been reperformed with a revised procedure.
Methods: Determination of Folic Acid in Various Dietary Supplement Dosage Forms UPLC/PDA.
Results: The recovery range of 94.6-106.5% was achieved by spiking 20, 50, and 80% on the gummy samples. Other adjustments or clarification of the method and minor typos were also addressed.
Conclusion: After the revised method, report, and results were analyzed and discussed, the ERP adopted the method and provided recommendations for achieving Final Action status.
Highlights: The revised method meets the requirements of SMPRSM 2022.002.
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