三叶草多糖对S180荷瘤小鼠的抗肿瘤及免疫调节作用。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-06-02 DOI:10.1002/jsfa.14415

Hongyun Song, Chuanbo Sun, Ning Li, Qun Zhao, Yanfei He

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引用次数: 0

摘要

背景：许多含有多叶蓼的中成药和中药方剂常被用作癌症的辅助治疗，目的是提高疗效，减轻不良反应。近年来的研究强调了草药多糖在抗肿瘤和免疫调节活性方面的重要作用。然而，何首乌多糖（PPP）对肿瘤和免疫的具体影响尚不清楚。结果：PPP分子量为10 692 Da。此外，PPP由10.29%的甘露糖、76.96%的葡萄糖、7.26%的半乳糖和5.49%的阿拉伯糖组成。PPP可显著抑制S180荷瘤小鼠的肿瘤增殖。它不仅能增强小鼠脾细胞的增殖和细胞毒性T淋巴细胞（CTL）活性，还能促进细胞因子的分泌。PPP也导致其脾细胞中Th1细胞因子（IL-2）和转录因子（T-bet和STAT4）的信使RNA表达增加。此外，PPP增强了S180荷瘤模型中Th2细胞因子（IL-4）及其相关转录因子（GATA3和STAT6）的表达。此外，PPP增强了肿瘤组织中炎症因子和趋化因子的分泌。此外，PPP显著提高了肿瘤组织中Caspase 3和Caspase 8的蛋白表达。结论：PPP通过诱导平衡的Th1/Th2免疫应答，重建S180荷瘤小鼠肿瘤免疫微环境，有效抑制肿瘤生长。©2025化学工业协会。

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Anti-tumor and immunomodulation activity of polysaccharide from Paris polyphylla Smith var. chinensis in S180 tumor-bearing mice.

Background: Many Chinese patent drug and Chinese herbal formulas containing Paris polyphylla Smith var. chinensis are frequently utilized as complementary treatments in cancer, aiming to enhance efficacy and mitigate adverse reactions. Recent studies highlight the crucial function of herbal polysaccharides in anti-tumor and immunomodulation activity. Yet, the specific impact of polysaccharides from Paris polyphylla (PPP) on tumor and immunity remains unclear.

Results: The molecular weight of PPP was 10 692 Da. Furthermore, PPP is comprised of 10.29% mannose, 76.96% glucose, 7.26% galactose, and 5.49% arabinose. PPP significantly curtailed tumor proliferation in S180 tumor bearing mice. It not only enhanced the proliferation and cytotoxic T lymphocyte (CTL) activity of splenocytes in these mice but also boosted the secretion of cytokines. PPP administration also led to an increased messenger RNA expression of Th1 cytokines (IL-2) and transcription factors (T-bet and STAT4) in their splenocytes. Additionally, PPP enhances the expression of Th2 cytokines (IL-4) and their associated transcription factors (GATA3 and STAT6) in the S180 tumor-bearing model. Moreover, PPP enhanced the secretion of inflammatory factors and chemokines in tumor tissues. Moreover, PPP markedly elevated the protein expression of Caspase 3 and Caspase 8 in tumor tissues.

Conclusion: PPP effectively suppressed tumor growth by inducing balanced Th1/Th2 immune response, and reconstructing the tumor immune microenvironment in S180 tumor bearing mice. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.