{"title":"月桂醇对植物病原真菌抑制机制的初步探讨","authors":"Yulan Ruan, Dianxian Cai, Yuefeng Li, Peiran Zhao, Yanhui Wu, Sijia Luo, Nianjia Li, Huiwen Yang, Shuyin Luo, Shijie You, Yutao Huang, Shurui Hu, Juejun Xing, Enwen Wu, Yizheng Xu, Zhangyong Dong, Min Luo, Xiaoming Peng, Guohui Yu, Yunhao Sun","doi":"10.1021/acs.jafc.5c00857","DOIUrl":null,"url":null,"abstract":"Lauryl alcohol, a naturally occurring compound widely used in food, pharmaceuticals, and surfactants, exhibits a potent antifungal activity. GZM, a plant protection formulation primarily composed of lauryl alcohol, is hypothesized to form a physical barrier on the plant surface. Here, we demonstrate that lauryl alcohol effectively reduces <i>Fusarium</i> head blight incidence and significantly inhibits <i>Fusarium graminearum</i>, <i>Fusarium oxysporum</i>, and <i>Colletotrichum gloeosporioides</i> in vitro. Using <i>Saccharomyces cerevisiae</i> as a model, we show that lauryl alcohol induces fungal apoptosis by disrupting mitochondrial function, impairing cell wall and membrane integrity, and increasing the number of reactive oxygen species. Transcriptome analysis reveals downregulation of genes involved in mitochondrial respiratory chain complex and ATP synthase biosynthesis. These findings highlight the potential of lauryl alcohol as a safe, eco-friendly fungicide for agricultural use.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"9 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preliminary Exploration of the Inhibitory Mechanism of Lauryl Alcohol on Plant Pathogenic Fungi\",\"authors\":\"Yulan Ruan, Dianxian Cai, Yuefeng Li, Peiran Zhao, Yanhui Wu, Sijia Luo, Nianjia Li, Huiwen Yang, Shuyin Luo, Shijie You, Yutao Huang, Shurui Hu, Juejun Xing, Enwen Wu, Yizheng Xu, Zhangyong Dong, Min Luo, Xiaoming Peng, Guohui Yu, Yunhao Sun\",\"doi\":\"10.1021/acs.jafc.5c00857\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lauryl alcohol, a naturally occurring compound widely used in food, pharmaceuticals, and surfactants, exhibits a potent antifungal activity. GZM, a plant protection formulation primarily composed of lauryl alcohol, is hypothesized to form a physical barrier on the plant surface. Here, we demonstrate that lauryl alcohol effectively reduces <i>Fusarium</i> head blight incidence and significantly inhibits <i>Fusarium graminearum</i>, <i>Fusarium oxysporum</i>, and <i>Colletotrichum gloeosporioides</i> in vitro. Using <i>Saccharomyces cerevisiae</i> as a model, we show that lauryl alcohol induces fungal apoptosis by disrupting mitochondrial function, impairing cell wall and membrane integrity, and increasing the number of reactive oxygen species. Transcriptome analysis reveals downregulation of genes involved in mitochondrial respiratory chain complex and ATP synthase biosynthesis. These findings highlight the potential of lauryl alcohol as a safe, eco-friendly fungicide for agricultural use.\",\"PeriodicalId\":41,\"journal\":{\"name\":\"Journal of Agricultural and Food Chemistry\",\"volume\":\"9 1\",\"pages\":\"\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Agricultural and Food Chemistry\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.jafc.5c00857\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1021/acs.jafc.5c00857","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Preliminary Exploration of the Inhibitory Mechanism of Lauryl Alcohol on Plant Pathogenic Fungi
Lauryl alcohol, a naturally occurring compound widely used in food, pharmaceuticals, and surfactants, exhibits a potent antifungal activity. GZM, a plant protection formulation primarily composed of lauryl alcohol, is hypothesized to form a physical barrier on the plant surface. Here, we demonstrate that lauryl alcohol effectively reduces Fusarium head blight incidence and significantly inhibits Fusarium graminearum, Fusarium oxysporum, and Colletotrichum gloeosporioides in vitro. Using Saccharomyces cerevisiae as a model, we show that lauryl alcohol induces fungal apoptosis by disrupting mitochondrial function, impairing cell wall and membrane integrity, and increasing the number of reactive oxygen species. Transcriptome analysis reveals downregulation of genes involved in mitochondrial respiratory chain complex and ATP synthase biosynthesis. These findings highlight the potential of lauryl alcohol as a safe, eco-friendly fungicide for agricultural use.
期刊介绍:
The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.