月桂醇对植物病原真菌抑制机制的初步探讨

IF 6.2 1区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Yulan Ruan, Dianxian Cai, Yuefeng Li, Peiran Zhao, Yanhui Wu, Sijia Luo, Nianjia Li, Huiwen Yang, Shuyin Luo, Shijie You, Yutao Huang, Shurui Hu, Juejun Xing, Enwen Wu, Yizheng Xu, Zhangyong Dong, Min Luo, Xiaoming Peng, Guohui Yu, Yunhao Sun
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引用次数: 0

摘要

十二烷基醇是一种天然存在的化合物,广泛应用于食品、药品和表面活性剂中,具有很强的抗真菌活性。GZM是一种主要由十二烷基醇组成的植物保护制剂,它被假设在植物表面形成物理屏障。本研究表明,月桂醇能有效降低赤霉病的发病率,并能显著抑制禾本科赤霉病、尖孢赤霉病和gloeosporioides炭疽病菌。以酿酒酵母为模型,我们发现月桂醇通过破坏线粒体功能、破坏细胞壁和膜的完整性以及增加活性氧的数量来诱导真菌凋亡。转录组分析显示参与线粒体呼吸链复合体和ATP合成酶生物合成的基因下调。这些发现突出了十二烷基醇作为一种安全、环保的农业杀菌剂的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Preliminary Exploration of the Inhibitory Mechanism of Lauryl Alcohol on Plant Pathogenic Fungi

Preliminary Exploration of the Inhibitory Mechanism of Lauryl Alcohol on Plant Pathogenic Fungi
Lauryl alcohol, a naturally occurring compound widely used in food, pharmaceuticals, and surfactants, exhibits a potent antifungal activity. GZM, a plant protection formulation primarily composed of lauryl alcohol, is hypothesized to form a physical barrier on the plant surface. Here, we demonstrate that lauryl alcohol effectively reduces Fusarium head blight incidence and significantly inhibits Fusarium graminearum, Fusarium oxysporum, and Colletotrichum gloeosporioides in vitro. Using Saccharomyces cerevisiae as a model, we show that lauryl alcohol induces fungal apoptosis by disrupting mitochondrial function, impairing cell wall and membrane integrity, and increasing the number of reactive oxygen species. Transcriptome analysis reveals downregulation of genes involved in mitochondrial respiratory chain complex and ATP synthase biosynthesis. These findings highlight the potential of lauryl alcohol as a safe, eco-friendly fungicide for agricultural use.
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来源期刊
Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry 农林科学-农业综合
CiteScore
9.90
自引率
8.20%
发文量
1375
审稿时长
2.3 months
期刊介绍: The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.
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