脑电图微观状态预测青少年吸烟者12小时戒断诱导的渴望变化

IF 3.6 2区 医学 Q1 PSYCHOLOGY, CLINICAL
Fang Dong , Zhimin Zhou , Zhiwei Ren , Yongxin Cheng , Yuxin Ma , Juan Wang , Ting Xue , Dahua Yu , Gengdi Huang , Kai Yuan , Xiaoqi Lu
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引用次数: 0

摘要

尼古丁戒断会抑制中脑边缘多巴胺系统增强渴望的功能。脑电微观状态可以提供脑神经元活动的时空特征。然而,关于戒烟后年轻吸烟者微观状态的时间动态和空间地形知之甚少。同时,为了探讨戒烟引起的渴望的神经生理机制,应用基线微观状态指标预测渴望的变化。本研究比较了53名年轻男性吸烟者和48名相匹配的非吸烟者的微观状态特征。为吸烟者设计了一个12小时的戒烟程序,并使用吸烟冲动问卷(QSU)测量他们的渴望程度。此外,根据戒烟后烟瘾变化是否增加,吸烟者被分为高烟瘾组和低烟瘾组。研究戒烟前后微状态指标的差异,探讨基线EEG微状态特征与吸烟渴望变化的关系。机器学习方法被用来预测戒断引起的渴望变化。我们观察到,在53名吸烟者中,12小时的戒烟过程显著降低了D类微观状态的解释方差、持续时间、发生率和覆盖率。戒断引起的渴望变化与基线时D类的解释方差、持续时间、发生率和覆盖率呈显著正相关。吸烟者的基线微观状态特征预测戒断引起的渴望变化的准确度为70.18%。这些发现表明,脑电图微状态特征可以作为年轻吸烟者戒断诱导渴望的关键功能生物标志物,为开发基于脑电图特征的个性化戒断干预策略提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Electroencephalography microstates predict 12-h abstinence-induced craving changes in young smokers

Electroencephalography microstates predict 12-h abstinence-induced craving changes in young smokers
Nicotine abstinence inhibits the function of the mesolimbic dopamine system to enhance craving. EEG microstates may provide spatiotemporal characteristics of global brain neuronal activity. However, little is known about the temporal dynamics and spatial topography of microstates in young smokers after abstinence. At the same time, in order to explore the neurophysiological mechanisms of craving induced by smoking abstinence, baseline microstates indicators were applied to predict craving changes. This study compared the microstates characteristics in 53 young male smokers and 48 matched nonsmokers. A 12-hour smoking abstinence procedure was designed for smokers, and their craving levels were measured using the Questionnaire on Smoking Urges (QSU). Furthermore, smokers were divided into high-craving and low-craving groups based on whether their craving changes increased after abstinence. We investigated the differences of microstates indicators before and after abstinence, and explored the relationships between baseline EEG microstates characteristics and smoking craving changes. The machine learning methods were used to predict abstinence-induced craving changes. We observed that the 12-h abstinence procedure significantly decreased the explained variance, duration, occurrence and coverage of microstates class D in 53 smokers. Craving changes induced by abstinence were significantly positively correlated with the explained variance, duration, occurrence and coverage of class D at baseline. The baseline microstates characteristics in smokers predicted abstinence-induced craving changes with an accuracy of 70.18%. These findings suggest that EEG microstates features can serve as key functional biomarkers for abstinence-induced craving in young smokers, providing novel insights for developing personalized abstinence intervention strategies based on EEG characteristics.
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来源期刊
Addictive behaviors
Addictive behaviors 医学-药物滥用
CiteScore
8.40
自引率
4.50%
发文量
283
审稿时长
46 days
期刊介绍: Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.
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