帕金森病丘脑游离水升高及其与淋巴功能障碍的关系:一项横断面和纵向研究

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Zhanyu Kuang , Xiaofei Huang , Mengfan Wang , Shuwen Bu , Riyu Guo , Yongzhou Xu , Amei Chen , Xinhua Wei
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引用次数: 0

摘要

游离水(FW)被认为是神经炎症的一个指标,而沿血管周围间隙扩散指数(ALPS)是最近引入的淋巴功能测量指标。然而,目前还没有研究同时调查这些因素之间的具体关系。本研究旨在研究帕金森病(PD)丘脑中线和外侧核FW的变化,特别关注淋巴系统功能障碍的潜在影响。MRI数据和临床信息来自32名健康对照(HC)、32名前驱PD (pPD)患者和90名PD患者,这些数据来自帕金森进展标志物倡议(PPMI)数据库。基于扩散张量图像计算ALPS指数和自由水分数体积(FWF)。分析组间比较及MRI指标与临床评价的相关性。与HC相比,双侧丘脑中线核、PD右侧核和pPD右侧中线核的FWF升高。PD组右侧丘脑外侧核ALPS指数与FWF呈显著负相关,右侧丘脑外侧核平均ALPS指数与FWF呈显著负相关。PD右侧丘脑外侧核的FWF与随访的蒙特利尔认知评估(MoCA)评分及其2年下降率相关。我们提供了间接证据支持PD参与者丘脑FW显著增加,可能因淋巴系统功能障碍而加剧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thalamic free water elevation and its association with glymphatic dysfunction in Parkinson’s disease: A cross-sectional and longitudinal study
Free Water (FW) is considered an indicator of neuroinflammation, while the Index of Diffusivity along the Perivascular Space (ALPS) is a recently introduced measure of glymphatic function. However, no study has yet investigated the specific relationships between these factors simultaneously. This study aimed to examine changes in FW in the thalamic midline and lateral nuclei in Parkinson’s disease (PD), with a particular focus on the potential influence of glymphatic system dysfunction. MRI data and clinical information were obtained from 32 healthy controls (HC), 32 participants with prodromal PD (pPD), and 90 participants with PD, sourced from the Parkinson’s Progression Markers Initiative (PPMI) database. The ALPS index and Free Water fractional volume (FWF) were calculated based on diffusion tensor images. Intergroup comparisons of and correlations among MRI measures and clinical assessments were analyzed. FWF was elevated in the bilateral thalamic midline and right lateral nuclei of PD and in right midline nuclei of pPD compared to HC. In the PD group, the right ALPS index was significantly and negatively associated with FWF in the bilateral thalamic lateral nuclei, and mean ALPS index was negatively correlated to FWF in right lateral nuclei. Moreover, FWF in the right lateral thalamic nuclei of PD was correlated with follow-up Montreal Cognitive Assessment (MoCA) scores and its 2-years decrease rate. We provided indirect evidence to support that thalamic FW was significantly increased in PD participants, potentially exacerbated by glymphatic system dysfunction.
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来源期刊
Neuroscience
Neuroscience 医学-神经科学
CiteScore
6.20
自引率
0.00%
发文量
394
审稿时长
52 days
期刊介绍: Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.
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