Albert Bellmunt-Gil, Joonas Majuri, Lauri Nummenmaa, Semi Helin, Sarita Forsback, Johan Rajander, Valtteri Kaasinen, Juho Joutsa
{"title":"赌博障碍的纹状体线索反应性和神经递质功能。","authors":"Albert Bellmunt-Gil, Joonas Majuri, Lauri Nummenmaa, Semi Helin, Sarita Forsback, Johan Rajander, Valtteri Kaasinen, Juho Joutsa","doi":"10.1556/2006.2025.00041","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Abnormal striatal cue reactivity is one of the neurobiological hallmarks of substance use disorders (SUDs). Cue reactivity is associated with relapse, prompting efforts to target its underlying mechanisms with therapeutic interventions. However, the neural correlates of cue reactivity in behavioral addictions, such as gambling disorder (GD), remain poorly understood. Here we investigated striatal cue reactivity and its associations with neurotransmitters in individuals with GD using multimodal neuroimaging.</p><p><strong>Methods: </strong>Thirteen subjects with GD and 16 healthy controls (HC) underwent fMRI using a block-design consisting of three different types of visual stimuli: gambling-related, erotic, and neutral videos. The subjects also underwent brain PET imaging with three radiotracers to assess dopamine ([18F]FDOPA), opioid ([11C]carfentanil) and serotonin ([11C]MADAM) function.</p><p><strong>Results: </strong>GD subjects showed a significantly greater BOLD response in the dorsal striatum compared to HC when viewing gambling-related versus neutral videos (pFWE<0.05). Enhanced cue-reactivity was specific to gambling, as there were no significant differences between the groups with natural reward cues (erotic vs. neutral videos). The dorsal and ventral striatum BOLD responses to gambling videos were coupled in HC (r = 0.7, p = 0.003) but not in GD (r = -0.1, p = 0.75; group difference p = 0.008). In GD, dorsal striatal BOLD response to gambling cues correlated with [11C]carfentanil, but not with [18F]FDOPA or [11C]MADAM, binding (r = 0.8, p < 0.001).</p><p><strong>Conclusions: </strong>GD is characterized by increased gambling cue-induced activity in the dorsal striatum, which is linked to mu-opioid receptor availability. The findings highlight the potential role of the mu-opioid system in mediating cue-reactivity in behavioral addictions.</p>","PeriodicalId":15049,"journal":{"name":"Journal of Behavioral Addictions","volume":" ","pages":"997-1009"},"PeriodicalIF":6.2000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231433/pdf/","citationCount":"0","resultStr":"{\"title\":\"Striatal cue-reactivity and neurotransmitter function in gambling disorder.\",\"authors\":\"Albert Bellmunt-Gil, Joonas Majuri, Lauri Nummenmaa, Semi Helin, Sarita Forsback, Johan Rajander, Valtteri Kaasinen, Juho Joutsa\",\"doi\":\"10.1556/2006.2025.00041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Abnormal striatal cue reactivity is one of the neurobiological hallmarks of substance use disorders (SUDs). Cue reactivity is associated with relapse, prompting efforts to target its underlying mechanisms with therapeutic interventions. However, the neural correlates of cue reactivity in behavioral addictions, such as gambling disorder (GD), remain poorly understood. Here we investigated striatal cue reactivity and its associations with neurotransmitters in individuals with GD using multimodal neuroimaging.</p><p><strong>Methods: </strong>Thirteen subjects with GD and 16 healthy controls (HC) underwent fMRI using a block-design consisting of three different types of visual stimuli: gambling-related, erotic, and neutral videos. The subjects also underwent brain PET imaging with three radiotracers to assess dopamine ([18F]FDOPA), opioid ([11C]carfentanil) and serotonin ([11C]MADAM) function.</p><p><strong>Results: </strong>GD subjects showed a significantly greater BOLD response in the dorsal striatum compared to HC when viewing gambling-related versus neutral videos (pFWE<0.05). Enhanced cue-reactivity was specific to gambling, as there were no significant differences between the groups with natural reward cues (erotic vs. neutral videos). The dorsal and ventral striatum BOLD responses to gambling videos were coupled in HC (r = 0.7, p = 0.003) but not in GD (r = -0.1, p = 0.75; group difference p = 0.008). In GD, dorsal striatal BOLD response to gambling cues correlated with [11C]carfentanil, but not with [18F]FDOPA or [11C]MADAM, binding (r = 0.8, p < 0.001).</p><p><strong>Conclusions: </strong>GD is characterized by increased gambling cue-induced activity in the dorsal striatum, which is linked to mu-opioid receptor availability. The findings highlight the potential role of the mu-opioid system in mediating cue-reactivity in behavioral addictions.</p>\",\"PeriodicalId\":15049,\"journal\":{\"name\":\"Journal of Behavioral Addictions\",\"volume\":\" \",\"pages\":\"997-1009\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231433/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Behavioral Addictions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1556/2006.2025.00041\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/2 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Behavioral Addictions","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1556/2006.2025.00041","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/2 0:00:00","PubModel":"Print","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Striatal cue-reactivity and neurotransmitter function in gambling disorder.
Background: Abnormal striatal cue reactivity is one of the neurobiological hallmarks of substance use disorders (SUDs). Cue reactivity is associated with relapse, prompting efforts to target its underlying mechanisms with therapeutic interventions. However, the neural correlates of cue reactivity in behavioral addictions, such as gambling disorder (GD), remain poorly understood. Here we investigated striatal cue reactivity and its associations with neurotransmitters in individuals with GD using multimodal neuroimaging.
Methods: Thirteen subjects with GD and 16 healthy controls (HC) underwent fMRI using a block-design consisting of three different types of visual stimuli: gambling-related, erotic, and neutral videos. The subjects also underwent brain PET imaging with three radiotracers to assess dopamine ([18F]FDOPA), opioid ([11C]carfentanil) and serotonin ([11C]MADAM) function.
Results: GD subjects showed a significantly greater BOLD response in the dorsal striatum compared to HC when viewing gambling-related versus neutral videos (pFWE<0.05). Enhanced cue-reactivity was specific to gambling, as there were no significant differences between the groups with natural reward cues (erotic vs. neutral videos). The dorsal and ventral striatum BOLD responses to gambling videos were coupled in HC (r = 0.7, p = 0.003) but not in GD (r = -0.1, p = 0.75; group difference p = 0.008). In GD, dorsal striatal BOLD response to gambling cues correlated with [11C]carfentanil, but not with [18F]FDOPA or [11C]MADAM, binding (r = 0.8, p < 0.001).
Conclusions: GD is characterized by increased gambling cue-induced activity in the dorsal striatum, which is linked to mu-opioid receptor availability. The findings highlight the potential role of the mu-opioid system in mediating cue-reactivity in behavioral addictions.
期刊介绍:
The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.