念珠阵的临床特点和目前的治疗方法：系统回顾。

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2025-05-29 DOI:10.1111/pde.15986

Adam C Yu, Dana Koroluk, Fatmah Alzahrani

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引用次数: 0

摘要

毛斑病是一种罕见的先天性头发疾病，其特征是由于各种角蛋白或粘粒蛋白4基因突变而导致毛干脆弱，呈串珠状。一项对24项研究（16项仅针对儿科，3项成人与儿童混合，3项仅针对成人，2项未明确）评估各种治疗方式的系统综述发现，局部和口服米诺地尔是最有效的治疗方法，而口服类维生素A和其他治疗方法的疗效不一。进一步的儿科研究和临床研究是评估长期治疗效果和探索新的治疗策略的必要条件。

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Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review.

Monilethrix is a rare congenital hair disorder characterized by fragile, beaded hair shafts due to mutations in various keratin or desmoglein 4 genes. A systematic review of 24 studies (16 pediatric only, 3 mixed adult and pediatric, 3 adult only, and 2 unspecified) evaluating various treatment modalities identified topical and oral minoxidil as the most effective therapies, while oral retinoids and other treatments showed variable efficacy. Further pediatric research and clinical studies are necessary to assess long-term treatment outcomes and explore novel therapeutic strategies for this challenging condition.

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.