Eun-Jung Park, You-Suk Lee, Eun-Min Jun, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee
{"title":"两种潜在的益生菌菌株弯曲乳酸杆菌WiKim0169和酸化Pediococcus WiKim0170在环磷酰胺诱导的免疫抑制大鼠模型中的免疫增强作用","authors":"Eun-Jung Park, You-Suk Lee, Eun-Min Jun, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee","doi":"10.1007/s12602-025-10585-4","DOIUrl":null,"url":null,"abstract":"<p><p>Emerging evidence suggests that probiotics are beneficial for immunity and play a crucial role in regulating gut microbiota. However, the immune-enhancing effects of specific bacterial species remain uncertain. This study investigated the effects of two potential probiotic strains, Latilactobacillus curvatus WiKim0169 (Wilac L004, W4) and Pediococcus acidilactici WiKim0170 (Wilac L002, W2) isolated from fermented cabbage, on immune enhancement and gut microbiota changes in a cyclophosphamide-induced immunosuppression rat model. The results revealed that W4 and W2 improved natural killer cell activity, serum nitrite, and immunoglobulin levels. They also increased cytokine levels and activated the nuclear factor-κB pathway, substantiating the underlying mechanism of the immune-enhancing effects. Additionally, both strains altered gut microbiota composition by increasing bacteria that are being studied for their potential association with immune function. Taken together, both strains improved immune-related biomarkers and the gut microbiota. These findings suggest W4 and W2 as promising probiotics with immune-enhancing properties.</p>","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immune-Enhancing Effects of Two Potential Probiotic Strains Latilactobacillus curvatus WiKim0169 and Pediococcus acidilactici WiKim0170 in a Cyclophosphamide-Induced Immunosuppression Rat Model.\",\"authors\":\"Eun-Jung Park, You-Suk Lee, Eun-Min Jun, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee\",\"doi\":\"10.1007/s12602-025-10585-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Emerging evidence suggests that probiotics are beneficial for immunity and play a crucial role in regulating gut microbiota. However, the immune-enhancing effects of specific bacterial species remain uncertain. This study investigated the effects of two potential probiotic strains, Latilactobacillus curvatus WiKim0169 (Wilac L004, W4) and Pediococcus acidilactici WiKim0170 (Wilac L002, W2) isolated from fermented cabbage, on immune enhancement and gut microbiota changes in a cyclophosphamide-induced immunosuppression rat model. The results revealed that W4 and W2 improved natural killer cell activity, serum nitrite, and immunoglobulin levels. They also increased cytokine levels and activated the nuclear factor-κB pathway, substantiating the underlying mechanism of the immune-enhancing effects. Additionally, both strains altered gut microbiota composition by increasing bacteria that are being studied for their potential association with immune function. Taken together, both strains improved immune-related biomarkers and the gut microbiota. These findings suggest W4 and W2 as promising probiotics with immune-enhancing properties.</p>\",\"PeriodicalId\":20506,\"journal\":{\"name\":\"Probiotics and Antimicrobial Proteins\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Probiotics and Antimicrobial Proteins\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s12602-025-10585-4\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Probiotics and Antimicrobial Proteins","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s12602-025-10585-4","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Immune-Enhancing Effects of Two Potential Probiotic Strains Latilactobacillus curvatus WiKim0169 and Pediococcus acidilactici WiKim0170 in a Cyclophosphamide-Induced Immunosuppression Rat Model.
Emerging evidence suggests that probiotics are beneficial for immunity and play a crucial role in regulating gut microbiota. However, the immune-enhancing effects of specific bacterial species remain uncertain. This study investigated the effects of two potential probiotic strains, Latilactobacillus curvatus WiKim0169 (Wilac L004, W4) and Pediococcus acidilactici WiKim0170 (Wilac L002, W2) isolated from fermented cabbage, on immune enhancement and gut microbiota changes in a cyclophosphamide-induced immunosuppression rat model. The results revealed that W4 and W2 improved natural killer cell activity, serum nitrite, and immunoglobulin levels. They also increased cytokine levels and activated the nuclear factor-κB pathway, substantiating the underlying mechanism of the immune-enhancing effects. Additionally, both strains altered gut microbiota composition by increasing bacteria that are being studied for their potential association with immune function. Taken together, both strains improved immune-related biomarkers and the gut microbiota. These findings suggest W4 and W2 as promising probiotics with immune-enhancing properties.
期刊介绍：
Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.
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