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The pooled relative risk (RR) of cognitive impairment among individuals with MetS was 1.34 (95% CI: 1.25-1.43), indicating a significant association. Subgroup analyses revealed that the NCEP-ATP III criteria more effectively identified this relationship compared to other diagnostic methods. The association appeared strongest in Asian populations, followed by European and American groups.</p><p><strong>Conclusion: </strong>This meta-analysis supports a significant association between MetS and cognitive impairment. Geographic variation in the strength of this relationship may be influenced by differences in diagnostic criteria and lifestyle factors. The findings underscore the importance of early screening and the development of region-specific public health interventions to mitigate cognitive decline in individuals with MetS.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"127-147"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between metabolic syndrome and cognitive impairment: a meta-analysis of analytical observational studies.\",\"authors\":\"Mobin Azami, Maryam Afraie, Pardis Mohammadzadeh, Asra Moradkhani, Matin Shanazari, Danial Soltanian, Yousef Moradi\",\"doi\":\"10.1080/13546805.2025.2503445\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The potential link between metabolic syndrome (MetS) and the risk of dementia or cognitive impairment remains uncertain. 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引用次数: 0
摘要
背景：代谢综合征（MetS）与痴呆或认知障碍风险之间的潜在联系仍不确定。本研究旨在通过对现有文献的综合回顾和荟萃分析来评估MetS与认知能力下降之间的关系。方法：系统检索截至2023年1月的Medline （PubMed）、Web of Science、Scopus和Embase数据库。符合条件的研究包括队列和病例对照设计。使用STATA version 17进行统计分析。结果：共纳入20项研究，包括5,727,594名参与者。met患者认知障碍的合并相对危险度（RR）为1.34 (95% CI: 1.25-1.43)，表明两者存在显著关联。亚组分析显示，与其他诊断方法相比，NCEP-ATP III标准更有效地确定了这种关系。这种关联在亚洲人群中表现得最为明显，其次是欧洲和美国人群。结论：该荟萃分析支持MetS与认知障碍之间的显著关联。这种关系强度的地理差异可能受到诊断标准和生活方式因素差异的影响。研究结果强调了早期筛查和发展特定区域的公共卫生干预措施的重要性，以减轻met患者的认知能力下降。
Association between metabolic syndrome and cognitive impairment: a meta-analysis of analytical observational studies.
Background: The potential link between metabolic syndrome (MetS) and the risk of dementia or cognitive impairment remains uncertain. This study aimed to assess the association between MetS and cognitive decline through a comprehensive review and meta-analysis of the existing literature.
Methods: A systematic search was conducted in Medline (PubMed), Web of Science, Scopus and Embase up to January 2023. Eligible studies included cohort and case-control designs. Statistical analyses were performed using STATA version 17.
Results: A total of 20 studies comprising 5,727,594 participants were included. The pooled relative risk (RR) of cognitive impairment among individuals with MetS was 1.34 (95% CI: 1.25-1.43), indicating a significant association. Subgroup analyses revealed that the NCEP-ATP III criteria more effectively identified this relationship compared to other diagnostic methods. The association appeared strongest in Asian populations, followed by European and American groups.
Conclusion: This meta-analysis supports a significant association between MetS and cognitive impairment. Geographic variation in the strength of this relationship may be influenced by differences in diagnostic criteria and lifestyle factors. The findings underscore the importance of early screening and the development of region-specific public health interventions to mitigate cognitive decline in individuals with MetS.
期刊介绍：
Cognitive Neuropsychiatry (CNP) publishes high quality empirical and theoretical papers in the multi-disciplinary field of cognitive neuropsychiatry. Specifically the journal promotes the study of cognitive processes underlying psychological and behavioural abnormalities, including psychotic symptoms, with and without organic brain disease. Since 1996, CNP has published original papers, short reports, case studies and theoretical and empirical reviews in fields of clinical and cognitive neuropsychiatry, which have a bearing on the understanding of normal cognitive processes. Relevant research from cognitive neuroscience, cognitive neuropsychology and clinical populations will also be considered.
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