TREM2在心血管疾病中的作用机制及治疗前景

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-05-15 DOI:10.1016/j.arr.2025.102774

Wengen Zhu , Yue Zhou , Yufan Wang , Linjuan Guo , Chen Liu

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引用次数: 0

摘要

心血管疾病（cvd）是全球死亡的主要原因，免疫反应在其发病机制中起着核心作用。髓样细胞上表达的触发受体2 （TREM2）是心血管疾病的关键免疫调节因子，影响炎症、脂质代谢和组织修复。本文综述了TREM2的结构、功能和信号通路，重点介绍了其在动脉粥样硬化、心肌梗死、高血压、心房颤动和心力衰竭中的作用。在动脉粥样硬化中，TREM2高表达的巨噬细胞（TREM2hi巨噬细胞）在早期促进斑块进展，但在晚期增强斑块稳定性。在心肌梗死中，TREM2调节巨噬细胞多样性和efferocytosis，帮助心脏修复。TREM2还通过减少炎症和促进组织修复在高血压性心脏病中发挥保护作用。靶向TREM2治疗的挑战包括其环境依赖性作用和复杂的信号通路。未来的研究应侧重于阐明TREM2在心血管疾病中的作用机制，并开发针对不同阶段的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TREM2 in cardiovascular diseases: Mechanisms and therapeutic perspectives

Cardiovascular diseases (CVDs) are the leading cause of global mortality, with immune responses playing a central role in their pathogenesis. Triggering receptor expressed on myeloid cells 2 (TREM2) is a key immune regulator in CVDs, influencing inflammation, lipid metabolism, and tissue repair. This review comprehensively examines TREM2's structure, function, and signaling pathways, highlighting its roles in atherosclerosis, myocardial infarction, hypertension, atrial fibrillation, and heart failure. In atherosclerosis, macrophages with high TREM2 expression (TREM2^hi macrophages) promote plaque progression in early stages but enhance plaque stability in advanced stages. In myocardial infarction, TREM2 modulates macrophage diversity and efferocytosis, aiding cardiac repair. TREM2 also plays a protective role in hypertensive heart disease by reducing inflammation and promoting tissue repair. Challenges in targeting TREM2 therapeutically include its context-dependent effects and complex signaling pathways. Future research should focus on elucidating TREM2's mechanisms in CVDs and developing stage-specific therapies.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.