基于SIX3OS1、miR-511-3p和RBP4联合构建脑卒中前期认知障碍预测模型

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-05-12 DOI:10.1016/j.neuroscience.2025.05.020

Te Wang , Rui Wang , Junsheng Zeng , Wei Zhao , Yan Liu , Hui Xiao

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引用次数: 0

摘要

背景：脑卒中的发病率呈逐年上升趋势。脑卒中后认知障碍（PSCI）是脑卒中最严重的并发症之一，缺乏有效的早期预测工具。方法：选取147例 S患者和80例健康人，收集相应的临床资料和血清样本。采用逆转录定量PCR （RT-qPCR）检测SIX3OS1、miR-511-3p和视黄醇结合蛋白4 （RBP4）的表达。将这些数据建立logistic回归模型，绘制受试者工作特征（ROC）曲线，评价SIX3OS1、miR-511-3p和RBP4的临床价值。结果：我们的研究发现SIX3OS1、miR-511-3p和RBP4在脑卒中中存在异常表达，三者联合检测的曲线下面积（AUC）为0.965。此外，ROC曲线显示SIX3OS1、miR-511-3p和RBP4联合预测PSCI的AUC为0.955。基于SIX3OS1 （X1）、miR-511-3p （X2）和RBP4 （X3）建立多元logistic回归预测模型，p = 1/[1 + e (7.190-5.400X1 + 11.109X2-3.585X3)]。结论：血清SIX3OS1、miR-511-3p和RBP4是脑卒中和PSCI患者的候选诊断生物标志物，与其他因素联合使用具有良好的诊断效果，可能成为PSCI新的治疗靶点。

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A novel predictive model constructed based on the combination of SIX3OS1, miR-511-3p and RBP4 for stroke-prost cognitive impairment

Background

The incidence of stroke is increasing year by year. Post-stroke cognitive impairment (PSCI) is one of the most serious complications of stroke, which lacks effective early prediction tools.

Methods

A total of 147 S patients and 80 healthy individuals were enrolled, with corresponding clinical data and serum samples collected. The expression of SIX3OS1, miR-511-3p and retinol binding protein 4 (RBP4) were detected by reverse transcription-quantitative PCR (RT-qPCR). These data were then used to build a logistic regression model, and receiver operating characteristic (ROC) curves were drawn to evaluate the clinical value of SIX3OS1, miR-511-3p and RBP4.

Results

Our study found that SIX3OS1, miR-511-3p and RBP4 abnormally expressed in stroke and the area under the curve (AUC) of the combined detection of these was 0.965. Additionally, ROC curve showed that the AUC of SIX3OS1, miR-511-3p and RBP4 combined was 0.955 for the prediction of PSCI. Based on SIX3OS1 (X1), miR-511-3p (X2) and RBP4 (X3), we developed multivariate logistic regression predictive model, p = 1/ [1 + e (7.190–5.400X1 + 11.109X2–3.585X3)].

Conclusion

Serum SIX3OS1, miR-511-3p and RBP4 are candidate diagnostic biomarker in stroke and PSCI patients, which achieve good diagnostic performance when used in combination with other factors, and may have the potential to be novel therapeutic targets for PSCI.

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.