树突状细胞亚群及其在免疫相关病理疾病中的作用概述。

IF 2.2 4区 工程技术 Q3 PHARMACOLOGY & PHARMACY
Bioimpacts Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI:10.34172/bi.30671
Mohsen Abbaszadeh, Bahar Naseri, Mohammad Taghizadeh-Teymorloei, Amirhossein Mardi, Mohammad Reza Javan, Javad Masoumi, Farid Ghorbaninezhad, Amirhossein Hatami-Sadr, Şengül Tural, Behzad Baradaran, Mohammad Reza Sadeghi
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引用次数: 0

摘要

树突状细胞(dc)是一种特殊的抗原呈递细胞(APCs),在先天免疫反应和适应性免疫反应之间起着连接作用。除了向T细胞呈递抗原外,树突状细胞还必须与细胞因子一起为T细胞提供共刺激信号,以诱导适当的细胞免疫反应。在稳态环境下,dc也能建立和维持耐受性。树突状细胞存在显著的表型异质性,每种树突状细胞具有不同的功能灵活性和各种标记的特异性表达。三种主要类型的dc包括传统dc (cdc)、浆细胞样dc (pDCs)和单核细胞衍生dc (moDCs)。朗格汉斯细胞(LCs)是另一种类型的树突细胞,存在于皮肤表皮层。由于DC的失调,DC可能被不恰当地定位或触发。这种现象可引起免疫反应失衡,甚至引起免疫相关病理疾病,即自身免疫性疾病和恶性肿瘤。本文通过对dc亚群在免疫系统中的个体发生、生物学、特征和功能的回顾,讨论了这些细胞在上述免疫相关疾病中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overview of dendritic cells subsets and their involvement in immune-related pathological disease.

Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) in linking innate and adaptive immune responses. In addition to presenting antigens to T cells, DCs must also provide co-stimulatory signals along with cytokines for T cells to induce an appropriate cellular immune response. Tolerance is also established and maintained by DCs under homeostatic circumstances. There is remarkable phenotypic heterogeneity in DCs, each with different functional flexibility and specific expression of various markers. The three primary categories of DCs comprise conventional DCs (cDCs), plasmacytoid DCs (pDCs), and monocyte-derived DCs (moDCs). Langerhans cells (LCs) are another type of DCs, which are found in the skin's epidermal layer. DCs may be positioned or triggered inappropriately as a result of dysregulation of DC. This phenomenon can cause an imbalance in immune responses and even immune-related pathological disorders, i.e., autoimmune diseases and malignancies. Herein, by reviewing the ontogeny, biology, characteristics, and function of DCs subsets in immune system, we discuss the contribution of these cells in the mentioned immune-related disorders.

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来源期刊
Bioimpacts
Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.80
自引率
7.70%
发文量
36
审稿时长
5 weeks
期刊介绍: BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.
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