{"title":"动物和植物蛋白如何影响超重和肥胖男性餐后阶段的能量代谢：一项交叉设计研究","authors":"Zahra Dehnavi, Shima Sabbaghi, Ali Jafarzadeh Esfehani, Mahnaz Namazi, Fahimeh Hoseinzadeh, Hanieh Barghchi, Monireh Dahri, Reza Rezvani, Mahdi Shadnoush, Mohammad Safarian","doi":"10.1186/s12937-025-01106-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Animal proteins (APs) and plant proteins (PPs) seem to exhibit different thermic and metabolic effects, which may be attributed to differences in amino acid profiles, bioavailability, and digestibility.</p><p><strong>Objectives: </strong>In this study, we aimed to investigate and compare the postprandial effects of AP and PP meals on energy metabolism parameters, including resting energy expenditure (REE) and substrate oxidation (SO), in overweight and obese men.</p><p><strong>Methods: </strong>This acute randomized crossover clinical trial involved forty-eight overweight and obese men, with a mean age of 33.48 ± 8.35 years and an average BMI of 29.15 ± 2.33 kg/m<sup>2</sup>. Participants consumed two high-protein test meals with different protein sources (AP and PP) on separate days, with a washout period of 7 to 10 days between them. On each test day, energy metabolism parameters were measured in both the fasting state and postprandial phase using indirect calorimetry. Statistical analysis was conducted using SPSS version 25 and R programs, evaluating the effects of carry-over, treatment, time, and treatment × time interaction through generalized estimating equations (GEE) analysis.</p><p><strong>Results: </strong>After controlling for baseline values, there was a significant effect of time (P < 0.05), protein source (P < 0.05), and protein source × time (P < 0.05) on REE, TEF, and carbohydrate oxidation. REE showed an increase following the consumption of both meals; however, the rise observed after AP (14.2%) was greater than that of PP (9.55%). The trends in TEF changes were similar to those of REE. The mean carbohydrate oxidation after consuming PP remained relatively stable throughout the test, whereas the AP meal gradually increased, reaching its peak at the 180th minute. The decline in carbohydrate oxidation was more pronounced following the AP meal than the PP meal by the end of the test.</p><p><strong>Conclusion: </strong>This clinical trial demonstrates that animal-based protein results in higher energy expenditure and carbohydrate oxidation than plant-based protein.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"63"},"PeriodicalIF":4.4000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013026/pdf/","citationCount":"0","resultStr":"{\"title\":\"How animal and plant-based proteins affect energy metabolism during the postprandial phase in overweight and obese men: a cross-over design study.\",\"authors\":\"Zahra Dehnavi, Shima Sabbaghi, Ali Jafarzadeh Esfehani, Mahnaz Namazi, Fahimeh Hoseinzadeh, Hanieh Barghchi, Monireh Dahri, Reza Rezvani, Mahdi Shadnoush, Mohammad Safarian\",\"doi\":\"10.1186/s12937-025-01106-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Animal proteins (APs) and plant proteins (PPs) seem to exhibit different thermic and metabolic effects, which may be attributed to differences in amino acid profiles, bioavailability, and digestibility.</p><p><strong>Objectives: </strong>In this study, we aimed to investigate and compare the postprandial effects of AP and PP meals on energy metabolism parameters, including resting energy expenditure (REE) and substrate oxidation (SO), in overweight and obese men.</p><p><strong>Methods: </strong>This acute randomized crossover clinical trial involved forty-eight overweight and obese men, with a mean age of 33.48 ± 8.35 years and an average BMI of 29.15 ± 2.33 kg/m<sup>2</sup>. Participants consumed two high-protein test meals with different protein sources (AP and PP) on separate days, with a washout period of 7 to 10 days between them. On each test day, energy metabolism parameters were measured in both the fasting state and postprandial phase using indirect calorimetry. Statistical analysis was conducted using SPSS version 25 and R programs, evaluating the effects of carry-over, treatment, time, and treatment × time interaction through generalized estimating equations (GEE) analysis.</p><p><strong>Results: </strong>After controlling for baseline values, there was a significant effect of time (P < 0.05), protein source (P < 0.05), and protein source × time (P < 0.05) on REE, TEF, and carbohydrate oxidation. REE showed an increase following the consumption of both meals; however, the rise observed after AP (14.2%) was greater than that of PP (9.55%). The trends in TEF changes were similar to those of REE. The mean carbohydrate oxidation after consuming PP remained relatively stable throughout the test, whereas the AP meal gradually increased, reaching its peak at the 180th minute. 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引用次数: 0
摘要
背景：动物蛋白（APs）和植物蛋白（PPs）似乎表现出不同的热代谢效应，这可能归因于氨基酸谱、生物利用度和消化率的差异。目的：在这项研究中，我们旨在调查和比较AP和PP餐后对超重和肥胖男性能量代谢参数的影响，包括静息能量消耗（REE）和底物氧化（SO）。方法：该急性随机交叉临床试验纳入48例超重和肥胖男性，平均年龄33.48±8.35岁，平均BMI为29.15±2.33 kg/m2。参与者在不同的日子里吃了两顿不同蛋白质来源（AP和PP）的高蛋白测试餐，其间有7到10天的洗脱期。在每个测试日，采用间接量热法测量空腹和餐后的能量代谢参数。采用SPSS version 25和R程序进行统计分析，通过广义估计方程（GEE）分析评估结转、治疗、时间和治疗×时间交互作用的效果。结果：在控制基线值后，时间的影响显著(P)。结论：本临床试验表明，动物蛋白比植物蛋白导致更高的能量消耗和碳水化合物氧化。
How animal and plant-based proteins affect energy metabolism during the postprandial phase in overweight and obese men: a cross-over design study.
Background: Animal proteins (APs) and plant proteins (PPs) seem to exhibit different thermic and metabolic effects, which may be attributed to differences in amino acid profiles, bioavailability, and digestibility.
Objectives: In this study, we aimed to investigate and compare the postprandial effects of AP and PP meals on energy metabolism parameters, including resting energy expenditure (REE) and substrate oxidation (SO), in overweight and obese men.
Methods: This acute randomized crossover clinical trial involved forty-eight overweight and obese men, with a mean age of 33.48 ± 8.35 years and an average BMI of 29.15 ± 2.33 kg/m2. Participants consumed two high-protein test meals with different protein sources (AP and PP) on separate days, with a washout period of 7 to 10 days between them. On each test day, energy metabolism parameters were measured in both the fasting state and postprandial phase using indirect calorimetry. Statistical analysis was conducted using SPSS version 25 and R programs, evaluating the effects of carry-over, treatment, time, and treatment × time interaction through generalized estimating equations (GEE) analysis.
Results: After controlling for baseline values, there was a significant effect of time (P < 0.05), protein source (P < 0.05), and protein source × time (P < 0.05) on REE, TEF, and carbohydrate oxidation. REE showed an increase following the consumption of both meals; however, the rise observed after AP (14.2%) was greater than that of PP (9.55%). The trends in TEF changes were similar to those of REE. The mean carbohydrate oxidation after consuming PP remained relatively stable throughout the test, whereas the AP meal gradually increased, reaching its peak at the 180th minute. The decline in carbohydrate oxidation was more pronounced following the AP meal than the PP meal by the end of the test.
Conclusion: This clinical trial demonstrates that animal-based protein results in higher energy expenditure and carbohydrate oxidation than plant-based protein.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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